The Effectiveness and Safety of 12-hour Versus 24-hour Magnesium Sulfate Regimen for the Management of Severe Preeclampsia in Sudanese Women: An Open Randomized Controlled Clinical Trial.

Samah Mohammed Ahmed Hussein0 个研究点目标入组 320 人开始时间: 2023年2月2日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Pregnant women with a viable fetus.
•Age from 18 to 44 years old.
•Admitted to the hospital's obstetrics unit for inpatient care.
•Diagnosed with severe preeclampsia.
•Severe preeclampsia is defined as blood pressure equal to or greater than 160/110 mm Hg at a single reading with proteinuria of 2+ on dipstick or 24-hour urinary protein of more than 5g, oliguria urine output of less than less than 30 mL/hour, cerebral or visual disturbances, renal failure as persistent oliguria despite of using of intravenous fluid and furosemide challenge with deranged serum electrolytes, rising creatinine greater than 1.5 mg/L, and urea greater than 45 mg/ dL”, pulmonary edema or cyanosis, epigastric or right upper quadrant pain, impaired liver function, thrombocytopenia, or fetal growth restriction.

•Women with any condition considered as a contraindication for MgSo4 therapy, like:
•Drug hypersensitivity
•Myasthenia gravis
•Prior intake of any other anticonvulsant
•History of epilepsy
•Women with diabetes mellitus.
•Women with HELP syndrome (hemolysis, elevated liver enzymes, and low platelets).

发起方

Samah Mohammed Ahmed Hussein