A comparative evaluation of nebulised and intravenous dexmedetomidine on attenuation of haemodynamic response to laryngoscopy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1. To assess the effect of nebulized and intravenous dexmedetomidine on mean
研究概览
简要总结
Dexmedetomidine is a highly selective alpha-2 adrenergic agonist. It is a short-acting sedative, hypnotic, anxiolytic, and analgesic with sympatholytic properties. Its pleiotropic effects have increasingly led to a reduction in anesthetic and analgesic requirements, hence used in the perioperative period. It can be used in various routes like intravenous, intramuscular, nasal, oral, subcutaneous, etc. In our study, we aim to study the efficacy of inhaled dexmedetomidine to intravenous dexmedetomidine in the suppression of intubation response. We hypothesize that dexmedetomidine, when given through the inhalation route, attenuates the intubation response with a better hemodynamic profile with minimal side effects in comparison with intravenous dexmedetomidine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Double Blind Double Dummy
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients undergoing elective surgeries under general anaesthesia
- •Patients belonging to American Society of Anaesthesiologists Physical Status (ASA-PS) 1 and 2.
排除标准
- •Patient refusal
- •Patient allergic to study drug
- •BMI > 30 kg/m
- •Patients with difficulty airway, unanticipated difficult laryngoscopy and intubation ( lasting > 15 seconds or more than 2 attempts at intubation)
- •Pregnancy and lactation.
- •Patient on opioids, sedatives, or beta blockers.
结局指标
主要结局
1. To assess the effect of nebulized and intravenous dexmedetomidine on mean
时间窗: 1. Following laryngoscopy at baseline, every minute for 5 minutes and at 10th minute.
arterial pressure response following laryngoscopy.
时间窗: 1. Following laryngoscopy at baseline, every minute for 5 minutes and at 10th minute.
次要结局
- 1. To determine the dose sparing effect of induction dose of propofol.(2. To assess the sedation scores preoperatively, using Modified Ramsay sedation score.)