Comparative Study on the Effects of Epidural Dexmedetomidine on Heart Rate Variability During General Anesthesia in Patients Undergoing Gastrectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- Heart rate variability analysis
研究概览
简要总结
The use of epidural dexmedetomidine decreases the anaesthetic requirements and improved postoperative pain. Dexmedetomidine is a potent and highly selective a2-adrenoceptor agonist and has sympatholytic effect. Power spectral analysis of heart rate variability(HRV) is a useful tool to assess cardiac autonomic activity. We investigated whether preemptive epidural dexmedetomidine can develop hemodynamic change and it could be identify patients by HRV.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients consented to spinal anesthesia were enrolled
- •Patients aged 40~70 years olds undergoing gastrectomy
- •No contraindication of epidural analgesia
- •ASA class I and II
- •Patients consented to epidural anesthesia were enrolled
排除标准
- •Patients with hypovolemia, coagulation disorders, local infection at the site of operation, history of headache, heart diseases, and history of allergy, chronic alcohol use or abuse, anemia, congenital heart diseases, bundle block, congestive heart failure or arrythmias
- •patients who had recently received sedative drugs or were under antidepressant treatment were not included in the study
研究组 & 干预措施
dexmedetomidine
干预措施: preemptive dexmedetomidine epidural bolus injection(1.5 mcg/kg) (Drug)
normal saline
干预措施: normal saline (Drug)
结局指标
主要结局
Heart rate variability analysis
时间窗: 5min perioids after fluid resuscitation.
Heart rate variability analysis was performed according to the Task Force recommendations. Frequency domain analysis was based on fast Fourier transformation. Power spectrum densities were calculated for low frequencies (LF: 0.04-0.15 Hz) and high frequencies (HF: 0.15-0.4 Hz) informalized units, defined as the LF or HF proportional part of the total power. Baseline and 30min after the injection of the study drug.
次要结局
- Epidural injection(at 30 min after the epidural injection of the study drug)