A study on memory T cell population in psoriatic lesion
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- 1. T cell density in lesional Vs perilesional skin.
研究概览
简要总结
The study aims to observe the skin resident memory T cell (Trm) population in psoriatic patients and to correlate with response to various treatment modalities already taken. Memory cells are found in increased numbers in active psoriatic lesions, and their density decreases with treatment. Whether there is a relation of memory T cell population with psoriasis severity or same site recurrence is yet to be detected. Establishing such a causal relation will be a breakthrough, helping in targeted therapy for psoriasis. Recent studies also show that memory T cell density can act as a predictor of prolonged course of disease, hence guiding the choice of treatments. Our hypothesis is that memory T cell density is decreased on effective treatment.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with psoriasis who give consent to participate in the study, irrespective of duration of psoriasis and treatment.
排除标准
- •1.Patients with active fever or severe infection.
- •2.Patients with other skin diseases or erythroderma.
- •3.Patients who had undergone other modalities of treatment- Ayurveda/Unani/Siddha/Homeopathy- in the past 3 months.
结局指标
主要结局
1. T cell density in lesional Vs perilesional skin.
时间窗: All outcomesare measured at baseline since it is a cross sectional observational study
2. Difference in density amon various treatment groups
时间窗: All outcomesare measured at baseline since it is a cross sectional observational study
次要结局
未报告次要终点