Population Research of Sublingual Microcirculation Data of Patients With Systemic Diseases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- Perfused small vessel density of sublingual small vessels measured by Cytocam
研究概览
简要总结
This is an observational clinical study, patients with systemic diseases will be enrolled according to the inclusion and exclusion criteria. Patients will received the examination of sublingual microcirculation by using incident dark field video microscope (Cytocam，Braedius Battery Powered Transilluminator). The microcirculation data includes total small vessel density, perfused small vessel density, microvascular flow index, and heterogeneity index. The patients will be divided into right groups according to their systemic diseases as follows: group 1 hypertension (60 patients), group 2 diabetes mellitus (60), group 3 hypertension and diabetes mellitus (60), group 4 end stage renal disease with hemodialysis (60), group 5 kidney transplant recipients (60), group 6 coronary artery disease (60), and group 7 peripheral arterial occlusive disease (60).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged from 20 to 79 years old
- •BMI ranged from 18.5 to 27 kg/m2
- •Presence of one of the condition
- •Diagnosed hypertension > 6 months, without other systemic diseases
- •Diagnosed diabetes mellitus > 6 months, without other systemic diseases
- •Diagnosed with both hypertension and diabetes mellitus > 6 months, without other systemic diseases
- •Diagnosed with end stage renal disease > 6 months
- •Received renal replacement therapy > 6 months
- •Diagnosed with coronary artery disease > 6 months
- •Diagnosed with peripheral arterial occlusive diseases > 6 months
排除标准
- •Diagnosed with sepsis, major trauma, or admission to ICU within one month
- •Body temperature higher than 37.5 ℃ or lower than 35.5 ℃
- •Any on of the following condition
- •Chronic obstructive pulmonary disease
- •Endocrine diseases
- •Hematological disorders
- •Uncured cancer
- •Chronic uncured infection
- •Other major disease with limited daily activity
- •Non-native speakers
结局指标
主要结局
Perfused small vessel density of sublingual small vessels measured by Cytocam
时间窗: Once at enrollment
次要结局
- Total small vessel density of sublingual small vessels measured by Cytocam(Once at enrollment)