IRCT2016031425726N4已完成未知
Effects of high dose vitamin D? ?as adjunctive therapy on ?clinical outcomes and prognostic biomarkers in patients with Acute ?Exacerbation of Chronic Obstructive ?? ?Pulmonary Disease. ?
Research council of School of Pharmacy, Shahid Beheshti University0 个研究点目标入组 70 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 70
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 40 years 至 139 years（—）
- 性别
- All
入选标准
- •Inclusion criteria include;
- •Vitamin D deficiency (serum 25(OH)D < 50 nmol/l) ?
- •Postbronchodilator FEV1/FVC < 0.70, FEV1< 80 % and
- •diagnosis acute exacerbation of COPD confirmed by a physician
- •Age=40 years ?
- •Written informed consent ?
- •Ability to comply with all study requirements
- •Exclusion criteria include
- •Severe vitamin D deficiency (serum 25(OH)D <15 nmol/l),?
- •Use of a supplement containing more than 400 IU vitamin D per day
- •Diagnosed asthma
- •Diagnosed osteoporosis
- •Self-reported history of hypercalcaemia or nephrolithiasis
- •Self-reported presence of sarcoidosis
- •Diagnosed chronic kidney disease stage 4 or higher (eGFR=29 ml/min/1.73 m2)?
- •liver insufficiency child pough class B or C
- •Interfering malignant diseases
- •Life expectation of less than 1 year on the basis of concurrent disease
- •Current participation in a clinical rehabilitation program
- •Pregnant or lactating women, or subjects who intend to become
- •pregnant within the study period
- •Potentially unreliable patients and those judged by the investigator
- •to be unsuitable for the study
- •Serious mental impairment i.e. preventing to understand the study
- •protocol or comply with the study aim.
排除标准
- 未提供
研究者
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