Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 2
- 主要终点
- changes in Transepidermal Waterloss by Tewameter
研究概览
简要总结
Comparison of a randomized, double-blind, and control-group study for the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants
详细描述
The aim is to investigate the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants by a randomized, double-blind, and control-group study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •> = 4 of Tewameter
排除标准
- •Within the last 6 months, took skin surgery including cosmetic purpose
- •Diabetic patients with poor glycemic control with a fasting blood glucose of 160 mg/dl or more
- •Creatinine levels: more than twice the normal upper limit
- •AST (GOT) or ALT (GPT) levels: more than twice the normal upper limit
- •Uncontrolled hypertension
- •sun allergy or sensitive skin
- •functional cosmetics that affect dermal moistures and wrinkles within the last 3 months.
- •If you have participated or are planning to participate in another clinical trial within the past month
- •Alcohol abuser
- •If they are pregnant or lactating or have a pregnancy plan during the clinical trial Those with allergic reactions to the constituent food
- •Any person deemed inappropriate by the researcher for other reasons
研究组 & 干预措施
Control group
1,000 mg of placebo (starch) was orally administered per day for 12 weeks
干预措施: placebo (starch) (Dietary Supplement)
CTP group
1,000 mg of collagen tripeptide (CTP) was orally administered per day for 12 weeks.
干预措施: CTP (Dietary Supplement)
结局指标
主要结局
changes in Transepidermal Waterloss by Tewameter
时间窗: baseline, after 6 weeks, and after 12 weeks
comparison between baseline, after 6 weeks, and after 12 weeks
次要结局
- changes in hydration level of the skin surface by Corneometer(baseline, after 6 weeks, and after 12 weeks)
- changes in skin wrinkling indices by Visiometer(baseline, after 6 weeks, and after 12 weeks)
- skin elasticity by Cutometer(baseline, after 6 weeks, and after 12 weeks)
研究者
Sang Yeoup Lee
Principal Investigator, Professor, Head of Integrated Research Institute for Natural Ingredients and Functional Foods (IRINIF)
Pusan National University Yangsan Hospital