anguage, speech and motor function in mild cognitive impairment due to AD and Alzheimer*s disease - Language, speech, motor function in MCI due to AD and AD

Hanzehogeschool Groningen0 个研究点目标入组 208 人开始时间: 待定最近更新: 2024年4月9日

试验速览

暂无简介。

•In order to be eligible to participate in this study:
•A subject with MCI with a likelihood of underlying AD pathophysiology must meet
•the following criteria:
•* Established diagnosis of MCI due to AD with a likelihood according to NIA-AA
•criteria (Albert et al., 2011).
•* A score of stage three on the Global Deterioration Scale (GDS) (Reisberg et
•al., 1982).
•A subject with AD must meet the following criteria:
•* Established diagnosis of AD (amnestic or non-amnestic) or etiologically mixed
•presentation of AD according to DSM-5 (American Psychiatric Association, 2013)
•or NINCDS-ARDRA criteria (Jack et al., 2018; McKann et al., 2011).
•* The following scores on the Global Deterioration Scale (GDS): four for mild
•AD, five for moderate AD (Reisberg et al., 1982).
•All subjects of the control group must meet the following criteria:
•* A score of stage one or two on the Global Deterioration Scale (GDS) (Reisberg
•et al., 1982).
•* They are age-matched with the MCI due to AD or AD patients included in the
•All subjects must meet the following criteria:
•* First language is Dutch and/or Frisian.
•* Able to walk independently with or without walking aid.
•* Able to squeeze with each hand.

•A subject with MCI due to AD or AD who meets the following criteria will be
•excluded from participation in this study:
•* Having a neurological or neurodegenerative disease or disorder that may be
•contributing to cognitive impairment above and beyond that caused by AD or
•mixed AD; Down*s syndrome, other subtypes of dementia, autism spectrum disorder.
•* Having an established diagnosis of a psychiatric disorder, e.g.
•schizophrenia, depression.
•All subjects in the control group who meets following criteria will be excluded
•from participation in this study:
•* Suffers from a neurological, neurodegenerative or psychiatric disease or
•All subjects in any group who meet any of the following criteria will be
•excluded from participation in this study:
•* Hearing loss (with or without hearing aid) that affects communication.
•* Vision loss (with or without glasses or lenses) that affects communication.
•* History of language problems, speech problems or dyslexia.
•* Suffers from additional disorders or diseases which may limit gait, hand grip
•strength, language and/or speech.
•* Medication use that influence gait, hand grip strength, speech or language
•performance at time of testing.
•* Being terminally ill (i.e., life expectancy < 2 weeks according to the
•attending physician).

发起方

Hanzehogeschool Groningen