Retrospective Comparison of the Effects of Granisetron and Aprepitant in the Prevention of Postoperative Nausea and Vomiting in Laparoscopic Abdominal Surgery
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- the need for additional antiemetics
研究概览
简要总结
The goal of this clinical trial is to compare frequency with postoperative nausea and vomiting in ASA( American Society of Anesthesiologists) I, II patients undergoing laparoscopic surgery.
The main question[s] it aims to answer are:
- Primary Outcome is the incidence of nausea and vomiting between 0-6 and 6-24 hours postoperatively and the need for additional antiemetics
- Secondary outcome is detection of additional analgesic needs and complications between 0-6 and 6-24 hours postoperatively.
Participants will receive aprepitant or granisetron for prevention of postoperative nausea and vomiting.
详细描述
The aim of this study is to investigate the effectiveness of drugs used for postoperative nausea and vomiting in laparoscopic surgeries.
In the research; During the operation, the patient's vitals will be recorded intraoperative forms. Vitals are; heart rate, blood pressure, oxygen saturation, end tidal carbon dioxide levels; according to the pain level after awakening from the patient follow-up forms in the service.
The doses and times of analgesics will be screened, the frequencies of postoperative nausea, retching, vomiting, and additional antiemetic doses will be screened, respiratory depression, complications of anesthesia, arrhythmia, laryngospasm, hypo-hypertension, headache, dizziness, allergic reactions anxiety symptoms will be screened too.
we will try to emphasize which antiemetic is more effective than the other and which one has few side effects
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA I, II patients patients undergoing laparoscopic surgery
排除标准
- •ASA III and above patients who refused to participate in the study
研究组 & 干预措施
Aprepitant
Substance P inhibitor chemotherapeutic and also useable for prevention of postoperative nausea and vomiting
干预措施: Aprepitant (Drug)
Granisetron
5- HT3( 5-hydroksitriptamine 3) antagonist drug for prevention of postoperative nausea and vomiting
干预措施: Granisetron (Drug)
结局指标
主要结局
the need for additional antiemetics
时间窗: postoperative 24 hours
the need for additional antiemetics between 0-6 and 6-24 hours postoperatively
incidence of vomiting
时间窗: postoperative 24 hours
the incidence of vomiting between 0-6 and 6-24 hours postoperatively
incidence of nausea
时间窗: postoperative 24 hours
the incidence of nausea between 0-6 and 6-24 hours postoperatively
次要结局
- additional analgesic need(postoperative 24 hours)
- detection of complications(postoperative 24 hours)
研究者
Begüm Nemika Gökdemir
Medical Doctor
Baskent University