The Impact of the Timing of Rocuronium After Induction With Propofol on Temporal Summation of Pain in Gynecologic Laparoscopic Surgery-prospective and Controlled Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- the grade of rocuronium induced withdrawal movement.
研究概览
简要总结
Temporal summation of pain, which is defined as the perception of increasingly greater pain evoked by repetitive painful stimuli, is highly variable between individuals. This study aimed to determine the impact of the timing of rocuronium after induction with propofol on temporal summation of pain in gynecologic laparoscopic surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
盲法说明
Attending anesthesiologist knew which anesthetic agents were used. However Outcomes assessor didn't know which anesthetic agents were used.
入排标准
- 年龄范围
- 19 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Elective gynecologic laparoscopic surgery
- •American Society of Anesthesiologists' physical status class) I-II
排除标准
- •Menopause (to exclude the hormonal effect on pain)
- •Patients who had muscular, cardiovascular, hepatic or kidney disorders and patients with a history of medication who would affect muscle relaxants were excluded from this study.
- •Patients with difficult venous access on forearm, a known allergy to propofol or rocuronium, chronic pain, pregnancy, and those who had received analgesics or sedatives within the previous 24 hours, were excluded from the study.
结局指标
主要结局
the grade of rocuronium induced withdrawal movement.
时间窗: during anesthesia induction
withdrawal movements were graded by the investigator according to the following scale: 1. - no pain (no response); 2. - mild pain (movement at wrist only); 3. - moderate pain (movement involving the arm only with elbow or shoulder); 4. - severe pain (generalized response or movement in more than one extremity
次要结局
- visual analog scale (VAS) for injection pain(during anesthesia induction)
- VAS for pain(at 1 hour, 24 hours and 48 hours)
- Patient controlled analgesia (PCA) Opioid consumption(at 24 and 48 hours)
研究者
Cheol Lee
Professor
Wonkwang University Hospital