Exercise Training, CACs, and Vascular Function in Older Veterans With IGT (Impaired Glucose Tolerance)
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Endothelial progenitor cell number
研究概览
简要总结
The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 50-80
- •Non-smoker
- •If woman, postmenopausal >1 year
排除标准
- •History of heart disease or stroke
- •Poorly controlled hypertension or dyslipidemia
- •Kidney or Liver diseases
结局指标
主要结局
Endothelial progenitor cell number
时间窗: 6-month
Skeletal muscle capillarization
时间窗: 6-month
次要结局
- Cardiorespiratory Fitness(6-month)
研究者
Steven J. Prior, Ph.D.
Assistant Professor
Baltimore VA Medical Center