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临床试验/CTRI/2024/03/063916
CTRI/2024/03/063916尚未招募3 期

Comparison of single vs triple aliquot injection for supraclavicular brachial plexus block in upper limb orthopaedic trauma surgeries : A Randomised controlled trial

AIIMS New Delhi1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2024年3月19日最近更新:

试验速览

阶段
3 期
状态
尚未招募
发起方
入组人数
50
试验地点
1
主要终点
To compare the anesthesia onset time

研究概览

简要总结

Supraclavicular block anesthetizes the brachial plexus where it is in its most compact form, thus providing a complete and reliable block for upper extremity surgery.1 Although the single injection (SI) ultrasound-guided corner pocket technique has been reported to have the highest success rate, this technique may miss the upper part of the plexus, resulting in an incomplete block. Cadaver and patient studies by using dye injections have demonstrated that injection into a single location does not result in the spread of the injected dye into all the compartments. Septae or a tight muscular membrane between the scalene muscles were found to separate roots of the plexus. Several studies comparing different approaches for brachial plexus block have demonstrated multiple injection techniques to be more successful, resulting in a faster onset of anesthesia and higher success rates with no increased incidence in complications. However, these trials did not show consistent results regarding the onset of block or the nerves blocked. The aim of this study was to compare the sensory block success rate of SI versus triple injection (TI). We hypothesized that a TI performed at the upper, middle, and lower parts of the plexus would have a higher success rate compared with the SI technique. In single injection using in plane approach a 22g 5 cm needle will be advanced until the tip is at the junction of first rib and subclavian artery.15 ml of 0.75% ropivacaine with 1 mcg/kg clonidine will be injected with negative aspiration. Similarly for  triple injection 5 ml each of the drug will be injected in corner , middle and above pocket. The time of onset of block will be measured as the primary outcome. We hypothesized that triple injection is more efficacious than single injection.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • Age 18-65 years 2) ASA 3)BMI<35kgm2.

排除标准

  • Patient refusal to participate 2)Known allergy to anesthetic drug 3)Infection at local site 4)Pregnancy and breast feeding 5)Known neuropathy involving upper extremities 6)Coagulation disorder 7)COPD and respiratory disorder.

结局指标

主要结局

To compare the anesthesia onset time

时间窗: 5 min 10 min 15 min 20 min 25 min 30 min

次要结局

  • 1)Duration of action(2)Duration of post op analgesia)

研究者

发起方
AIIMS New Delhi
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr.Babita Gupta

All India Institute of Medical Sciences

研究点 (1)

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