Clinical Indicators and Brain Image Data: a Cohort Study Based on Kailuan Cohort
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 2
- 主要终点
- White matter hyperintensity of the brain measured by MRI (magnetic resonance imaging)
研究概览
简要总结
The investigators will analyze the relationship between the medical history, physiological indicators and the cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs in a large sample size of subjects (participants), to identify the influencing factors of the occurrence and development of cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs, so as to provide objective clues for early intervention of the disease and improve clinical outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age from 18 to 90 years old;
- •Comes from the Kailuan Cohort, completed ≥1 visits which the medical history, physiological indicators were measured;
- •Without contraindications of CT and MR scan;
- •Can cooperate with the measurement of the medical history, physiological indicators and brain imaging.
排除标准
- •Known clinical history with congenital or acquired organic diseases (such as aortic stenosis);
- •Known history of drug abuse;
- •Pregnant and lactating women;
- •With clinical history of psychiatric diseases (such as schizophrenia).
结局指标
主要结局
White matter hyperintensity of the brain measured by MRI (magnetic resonance imaging)
时间窗: every two years up to 30 years
microbleeds of the brain measured by MRI (magnetic resonance imaging)
时间窗: every two years up to 30 years
White matter microstructural integrity of the brain measured by MRI (magnetic resonance imaging)
时间窗: every two years up to 30 years
Cerebral blood flow measured by MRI (magnetic resonance imaging)
时间窗: every two years up to 30 years
Brain volume measured by MRI (magnetic resonance imaging)
时间窗: every two years up to 30 years
Lacunes of the brain measured by MRI (magnetic resonance imaging)
时间窗: every two years up to 30 years
次要结局
- Blood pressure (both Systolic and Diastolic Blood Pressure)(every two years up to 30 years)
- BMI (body mass index)(every two years up to 30 years)
- blood glucose level(every two years up to 30 years)
- Cervical vascular ultrasound(every two years up to 30 years)
- Fundus optical coherence tomography (OCT)(every two years up to 30 years)
- Fundus color photography of the eyes(every two years up to 30 years)
- Uric acid(every two years up to 30 years)
研究者
Wang, Zhenchang
Professor
Beijing Friendship Hospital