The Effect of Thyroid Lobe Volume on the Common Carotid Artery Blood Flow in Thyroidectomy Position
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 132
- 试验地点
- 1
- 主要终点
- Change in Systolic/Diastolic Flow Time Ratio of the Common Carotid Artery
研究概览
简要总结
The goal of this observational study is to evaluate how thyroid lobe volume affects carotid artery blood flow dynamics in adult patients undergoing elective thyroidectomy. The study includes male and female participants aged 18 years and older who have euthyroid function and are scheduled for elective thyroidectomy.
The main questions it aims to answer are:
- Does thyroid lobe volume influence carotid artery blood flow characteristics, particularly systolic/diastolic flow time ratios, during thyroidectomy?
- What is the optimal thyroid lobe volume cutoff for predicting altered systolic/diastolic flow time ratios (<0.3)?
Participants will:
- Undergo Doppler ultrasound measurements at three time points: before anesthesia induction, after anesthesia induction, and after surgical positioning.
- Have their carotid artery blood flow and regional cerebral oxygenation values assessed.
No comparison groups are involved, as all participants will be observed under the same conditions.
详细描述
This observational study investigates how the size of the thyroid gland affects blood flow in the common carotid artery during thyroidectomy, a surgical procedure to remove part or all of the thyroid gland. The thyroid gland is anatomically close to the carotid artery, a major blood vessel supplying blood to the brain. Enlarged thyroid lobes may compress the artery, potentially altering blood flow dynamics, particularly during the semi-Fowler's position required for the surgery. By examining these effects, this study aims to provide insights into the interplay between thyroid anatomy and carotid blood flow, which could have implications for surgical and anesthetic management.
Study Objectives
The primary objective is to determine the relationship between thyroid lobe volume and carotid artery blood flow during thyroidectomy. Specifically, the study seeks to:
- Evaluate how thyroid lobe volume influences systolic and diastolic blood flow in the carotid artery.
- Identify a thyroid lobe volume cutoff associated with significant alterations in systolic/diastolic flow time ratios (<0.3).
Study Population
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (≥18 years old) scheduled for elective thyroidectomy.
- •Patients in a euthyroid state as confirmed by recent laboratory tests.
- •Ability to provide written informed consent.
排除标准
- •Pregnant patients.
- •Emergency thyroidectomy cases.
- •History of subtotal thyroidectomy.
- •History of allergic reaction to anesthetic agents.
- •Presence of anemia (hemoglobin levels below local institutional thresholds).
- •Presence of labile hypertension (documented by repeated measurements on the surgical ward)
- •Presence of abnormal thyroid hormone levels.
结局指标
主要结局
Change in Systolic/Diastolic Flow Time Ratio of the Common Carotid Artery
时间窗: Measured at baseline (T0), post-anesthesia induction (T1), and post-surgical positioning (T2).
Assess the relationship between thyroid lobe volume and alterations in the systolic/diastolic flow time ratio during thyroidectomy.
Thyroid Lobe Volume Cutoff for Altered Flow Dynamics
时间窗: Post-hoc analysis using data from baseline (T0).
Determine the thyroid lobe volume cutoff associated with a systolic/diastolic flow time ratio \<0.3.
次要结局
- Change in Carotid Artery Blood Flow(Measured at baseline (T0), post-anesthesia induction (T1), and post-surgical positioning (T2).)
- Regional Cerebral Oxygenation Changes(Measured at baseline (T0), post-anesthesia induction (T1), and post-surgical positioning (T2).)
研究者
Başar Erdivanlı
Assoc. Prof.
Recep Tayyip Erdogan University