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临床试验/NCT02960958
NCT02960958Unknown不适用

Metabolome Analysis in Patients With Rheumatoid Arthritis

The Catholic University of Korea0 个研究点目标入组 200 人开始时间: 2016年11月20日最近更新:
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适应症

试验速览

阶段
不适用
入组人数
200
主要终点
Metabolic fingerprint of rheumatoid arthritis
研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

The aim of this study is to investigate discriminant metabolites in urine from patients with rheumatoid arthritis (RA) from healthy individuals. Then we determine if the patient's metabolic fingerprint could predict the development or flare-up of RA.

详细描述

Compare metabolites between RA patients and healthy individuals.

  1. Collection urine sample
  2. Assessing urine metabolites by 1H NMR spectroscopy
  3. Analyzing the relationships between metabolites and clinical variables

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —（Adult, Older Adult）
性别
All
接受健康志愿者
是

入选标准

  • •All patients with rheumatoid arthritis meet 2010 American College of Rheumatology/European League against Rheumatism classification criteria.

排除标准

  • •Comorbid with other autoimmune diseases
  • •Confirmed with amyloidosis
  • •Chronic kidney disease (estimated GFR < 60 ml/min/1.73m2)
  • •Chronic liver disease
  • •Thyroid disease
  • •Pregnancy
  • •Solid tumor/hematologic malignancy within 5 years

结局指标

主要结局

Metabolic fingerprint of rheumatoid arthritis

时间窗: 1 years

Metabolomic analyses of urine from patients with rheumatoid arthritis, healthy controls and other autoimmune disease

次要结局

  • Correlations between specific metabolites and disease activity/severity of RA(1 year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jung Hee Koh

MD

The Catholic University of Korea

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Metabolome Analysis in Patients With Rheumatoid... | 临床试验