ISRCTN92545532已完成未知
A prospective, double-blind, randomised, parallel group, placebo-controlled trial of metformin treatment for renal angiomyolipomas in tuberous sclerosis complex
niversity Hospitals Bristol NHS Foundation Trust (UK)0 个研究点目标入组 55 人开始时间: 2011年5月11日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 55
研究概览
简要总结
2021 results in https://pubmed.ncbi.nlm.nih.gov/33681737/ (added 09/03/2021)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Clinically definite diagnosis of TSC (modified Gomez criteria)
- •2. Age between 10 to 65 years
- •3. One or more renal angiomyolipoma of at least one centimetre in largest diameter
- •4. Signed informed consent
排除标准
- •1. Serious intercurrent illness or uncontrolled disease which could compromise
- •participation in the study
- •2. Impairment of renal function
- •3. Use of x-ray contrast medium containing iodine within the last 30 days
- •4. Multiple renal angiomyolipomas where individual lesions cannot be distinguished (and
- •as such cannot be accurately measured)
- •5. Renal haemorrhage within the preceding year
- •6. Known conservatively managed renal aneurysm(s) greater than 10mm
- •7. Liver insufficiency
- •8. Acute or chronic disease which may cause tissue hypoxia e.g.cardiac/respiratory failure,
- •recent myocardial infarction, shock
- •9. Diabetes
- •10. Treatment with any injected or oral hypoglycaemic drug
- •11. Use of an investigational drug within the last 30 days
- •12. Pregnant or intending to become pregnant during the study period
- •13. Breastfeeding
研究者
相似试验
已完成
不适用
COPE-POMP: 'in house' pre-implantation oxygenated hypothermic machine perfusion reconditioning after cold storage versus cold storage alone in expanded criteria donor (ECD) kidneys from brain dead donorsISRCTN63852508niversity of Oxford (UK)262
已完成
不适用
Cold oxygenated machine preservation of aged renal donation after cardiovascular death transplantsMachine perfusion preservation techniques of kidney graftsInjury, Occupational Diseases, PoisoningISRCTN32967929niversity of Oxford (UK)197
进行中（未招募）
不适用
A pilot study to evaluate automatic deep vein thrombosis diagnostic softwareDeep vein thrombosisCirculatory SystemPhlebitis and thrombophlebitis of other deep vessels of lower extremitiesISRCTN11069056Oxford University Hospitals NHS Trust400
已完成
4 期
Evaluation of Lactosectan versus placebo to compare the effectiveness and safety in treating adult patients with intolerance to certain foods, primarily lactose intoleranceactose intoleranceNutritional, Metabolic, EndocrineLactose intoleranceISRCTN18410689ovintethical Pharma SA60
已完成
2 期
stekinumab in adolescents with recent-onset type 1 diabetesNutritional, Metabolic, EndocrineType 1 diabetes mellitusISRCTN14274380Cardiff University88