The Epigenetics of Exercise and Physical Activity in COPD
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Change in DNA methylation patterns
研究概览
简要总结
This study seeks to examine genome-wide DNA methylation patterns associated with physical activity and exercise capacity from peripheral blood collected from participants with chronic obstructive pulmonary disease (COPD) before and after participation in a structured 9-week outpatient pulmonary rehabilitation program.
详细描述
Individuals who are referred to pulmonary rehabilitation IN THE COURSE OF THEIR USUAL CLINICAL CARE will be invited to participate in this observational study. Participants who enroll in the study will undergo two in-person visits, once before initiating pulmonary rehabilitation classes and once at the conclusion of pulmonary rehabilitation classes. Participation in this study will not alter the course of the participants' usual clinical care.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >40 years
- •Diagnosis of COPD (defined as an FEV1/FVC<0.7 or evidence of emphysema on radiologist's read of a chest CT obtained in the course of patient's usual care)
- •Referral to and participation in the VA Boston Pulmonary Rehabilitation program
排除标准
- •Active or unstable cardiac disease
- •Inability to ambulate > 1 block
- •Recent acute exacerbation of COPD (defined as new or increased dose of systemic steroids and/or antibiotics for pulmonary indications)
结局指标
主要结局
Change in DNA methylation patterns
时间窗: Baseline and 3-month follow up
Baseline patterns and changes over time after participation in exercise training
次要结局
- Change in average daily step count(Baseline and 3-month follow up)
- Change in 6MWD(Baseline and 3-month follow up)
研究者
Emily S. Wan
Physician and Principal Investigator
VA Boston Healthcare System