A Randomized Study to Evaluate the Effectiveness of Cholecalciferol Versus Ergocalciferol Following Kidney Disease Outcomes Quality Initiative (K/DOQI) Guidelines for Vitamin D Therapy in Stages 3 & 4 Chronic Kidney Disease (CKD) Patients
试验速览
- 阶段
- 3 期
- 状态
- 终止
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Subjects Achieving Normal Vitamin D Levels
研究概览
简要总结
The purpose of this study is to examine the effectiveness of vitamin D3 versus vitamin D2 in raising vitamin D levels and suppressing parathyroid hormone levels in patients with kidney disease who are not on dialysis.
详细描述
Subjects will be randomized and assigned to one of the treatment groups (D2 or D3). Subjects will be dispensed a supply of 1.25 mg cholecalciferol/ergocalciferol tablets, depending on their randomization outcome. The number of pills dispensed and medication instructions will be determined by their 25OHD level and K/DOQI guidelines. Both Study personnel and subject will be blinded to randomization group.
The treatment phase will be 24 weeks in duration with lab visits every 6 weeks. All laboratory specimens will be drawn either at CCF Main hospital labs or at a CCF family Health center lab. Subjects will be have telephone interviews at week 4, 10, 16, 22 and possibly at weeks 28 and 34.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults ≥ 18 years
- •Chronic kidney disease stage 3-4 (eGFR 15-59 mL/min/1.73m2 body surface area, calculated using the MDRD Study equation GFR calculator)
- •Hypovitaminosis D (serum 25OHD < 31 ng/mL)
- •Secondary hyperparathyroidism (Intact PTH > 70 pg/mL for stage 3, and iPTH > 110 pg/mL for stage 4)
排除标准
- •Initiation of vitamin D therapy between the time of the lab draw used for screening and the screening process
- •History of liver failure
- •History of intestinal malabsorption or chronic diarrhea
- •Serum calcium level greater than 10.2 mg/dL
- •Treatment with an activated vitamin D formulation (calcitriol, doxercalciferol or paricalcitol) within the past 6 months
- •Treatment with phenobarbital, phenytoin, rifampicin, sucralfate, steroids, digoxin, or other medications that could affect vitamin D metabolism
- •Primary hyperparathyroidism, active of a prior history of such
- •Active malignancy excluding basal cell or localized squamous cell skin cancer
- •Subject is pregnant (e.g. positive HCG test) or breast-feeding
- •Refusal to use highly effective contraceptive measures (as determined by the investigator) throughout the treatment phase of the study
- •Serum phosphorus level greater than 4.5 or treatment with an oral phosphate binder within the past 6 months
- •Treatment with cinacalcet or other calcimimetic within the past 6 months
- •Anticipated dialysis within 6 months after randomization
- •Inability to swallow tablets
- •Known sensitivity, intolerance, or other adverse response to the study drugs which would prevent compliance with study medication
- •Have an unstable medical condition, defined as having been hospitalized within 30 days before screening, the expectation of recurrent hospital admissions or life expectancy of less than 6 months in the judgment of the investigator
- •Subject is currently enrolled in, or fewer than 30 days have passed since subject has completed another investigational device or drug study(s); or subject is receiving another investigational agent(s).
- •Current treatment with vitamin D 50,000 IU
研究组 & 干预措施
Vitamin D2
Patients randomized to take vitamin D2
干预措施: Ergocalciferol (Drug)
Vitamin D3
Patient's randomized to take Vitamin D3
干预措施: Cholecalciferol (Drug)
结局指标
主要结局
Subjects Achieving Normal Vitamin D Levels
时间窗: within 24 weeks
次要结局
未报告次要终点