Does Creatine Enhance the Effects of Cognitive Training in Older Adults with Mild Cognitive Impairment?

niversity of Sydney0 个研究点目标入组 50 人开始时间: 2016年4月18日最近更新: 2020年1月13日

适应症

试验速览

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•1. Aged 60 years or older;
•2. Ability to read, write and communicate in English;
•3. Ability to attend two sessions per week for 12 weeks at the training centre;
•4. Sufficient physical abilities (motor, eyesight, hearing) to use a computer;
•5. Cognitive impairment in memory or other cognitive domain (i.e., 1.5 SD below their
•expected level of performance based on normative data), measured within the last 6 months;
•6. MCI diagnosis: this will be determined by consensus of three independent clinician raters and will follow Winblad’s criteria.

•1. Bayler-ADL > 3.0
•2. MMSE < 24
•3. Geriatric Depression Scale > 7
•4. Intellectual disability
•5. Current diagnosis of:
•- Dementia,
•- Major Depressive Episode (within the last 6 months),
•- Neurological illness (e.g. epilepsy, Parkinson’s Disease),
•- Non-affective psychiatric illness (e.g. schizophrenia),
•- Loss of consciousness >30-minutes in the past 12 months,
•- Diabetes and/or insulin resistance,
•- Renal impairment (defined by serum creatinine-estimated Glomerular Filtration Rate <60mL/min)
•- Gastrointestinal disease or food allergies (e.g. coeliac disease, corn starch allergy and/or irritable bowel syndrome).
•6. Electroconvulsive Therapy
•7. Current/past alcohol or substance dependence (other than nicotine)
•8. Use of cholinesterase inhibitors or other cognitive enhancing drugs
•9. Current treatment with diuretics, NSAIDS, Probenecid, Cimetidine, aminoglycoside
•antibiotics and/or lansopraxolem
•10. Clinical history of hepatic disease or chronic or acute renal impairment or failure
•11. Presence of abnormal Liver Function Test results: abnormality defined on ANY of the
•following as per local laboratory thresholds: albumin, alanine transaminase ALT,
•aspartate transaminase AST, alkaline phosphatase ALP, bilirubin, gamma glutamyl
•transpeptidase GGT).

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