Validation of a Predictive Rule for the Diagnosis of Viral Meningitis in Adult Emergency Departments
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- External validation of the BMS score in a European adult population to exclude bacterial meningitis
研究概览
简要总结
Meningitis is the development of an inflammatory reaction in the meningeal space, most often of infectious origin. Many pathogens can cause meningitis, the severity of which varies greatly. Patients presenting with a febrile meningeal syndrome are most often managed in the emergency room, where the challenge for physicians is to quickly differentiate bacterial and viral meningitis.
Viral meningitis is the most common, with enterovirus meningitis having a classically excellent prognosis. Bacterial meningitis is less frequent but more serious.The current public health objective is to save antibiotics.
Investigator hypothesizes that the BMS score can be used to exclude bacterial meningitis in the emergency department in an adult European population of patients with suspected bacterial meningitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient admitted to the Adult Emergency Department of CH Le Mans,CHU Angers, CHU Nantes or Beaujon Hospital.
- •Over 18 years old
- •Having had a lumbar puncture during their stay in the Adult Emergency Department
- •Having had a diagnosis of meningitis defined as a pleocytosis ≥ 5leukocytes/mm3 after correction with CSF red blood cells at a standardized ratio of 500/1.
排除标准
- •Antibiotic therapy within 72 hours of inclusion
- •Immunosuppression from any cause
- •Presence of petechiae or purpura
- •History of recent neurosurgery or head trauma
- •Other associated bacterial infection
- •Inability to collect information for the BMS score calculation or primary endpoint (e.g., transfer to another facility)
- •Minor or adult patient under guardianship or protection
结局指标
主要结局
External validation of the BMS score in a European adult population to exclude bacterial meningitis
时间窗: 1 month after inclusion
Validation was measured by comparaison between BMS score and the diagnosis retained from the data collected in the file
次要结局
未报告次要终点