Does Vitamin C Increase the Body Heat Generated By The Nervous System?
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Body Temperature
研究概览
简要总结
The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for overweight based on body mass index. The main question it aims to answer are:
- By how much does body temperature increase during stimulation of beta-adrenergic receptors when vitamin C is given.
- By how much does circulating vitamin D concentration increase during stimulation of beta-adrenergic receptors when vitamin C is given.
Participants will will be asked to:
- undergo measures of body temperature
- have blood sampled on two separate occasions: once during stimulation of beta adrenergic receptors, and once during stimulation of beta-adrenergic receptors while also been given vitamin C.
详细描述
Participants will be required to visit the lab twice. During each visit, beta-adrenergic receptors will be stimulated with isoproterenol. The two visits are identical in every way with one exception: during one visit the isoproterenol will be delivered with saline only, and during the other visit the isoproterenol will be delivered with saline and vitamin C. The order of the visits will be randomized. Body temperature will be measured with a thermometer and a thermal camera. venous blood will be sampled and circulating vitamin D concentration will be quantified.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-40 years (inclusive)
- •Body mass index greater than or equal to 25 kg/m2 and less than 30 kg/m2
- •Weight stable (no change in body mass greater than 5 Lbs. within the previous 6 months.
- •Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits
- •Competency in English as assessed by comprehension of the Informed Consent. This is study involves invasive procedures and infusion of a systemic vasoactive agent (isoproterenol); for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.
排除标准
- •History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
- •Pregnancy or breast feeding
- •Habitual use of tobacco/nicotine products or recreational drugs (2 or more uses within the previous month)
- •History of a "sulfite allergy" as it is a relative contraindication to isoproteronol use.
- •Has ingested vitamin supplements and/or antioxidant supplements during the previous 4-weeks (e.g. Vitamin C, Vitamin E, Multi-vitamins, etc.)
研究组 & 干预措施
Response to beta-adrenergic stimulation without vitamin C
Isoproterenol will be infused with saline only
Adding vitamin C to beta-adrenergic receptor stilmulation
Isoproterenol will be infused with vitamin C
干预措施: Vitamin C (Other)
结局指标
主要结局
Body Temperature
时间窗: Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.
Body temperature will be measured using an oral thermometer
Vitamin D
时间窗: Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.
Circulating vitamin D concentration
次要结局
未报告次要终点