The Influence of Pain on Exercise-Induced Hypoalgesia in Healthy Subjects: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Pressure pain threshold at the right quadriceps muscle where injection is performed.
研究概览
简要总结
The purpose of this study is to investigate how acute pain induced by hypertonic saline prior to exercise influence the magnitude of exercise-induced hypoalgesia after a 3 min isometric wallsquat exercise in healthy subjects. The study is a single blinded (investigator) randomized cross-over trial The results from the study may be of great importance to the understanding of exercise-induced hypoalgesia, and whether the presence of pain affects the effects of exercise.
详细描述
Exercise is recommended to promote and maintain health and as treatment for more than 25 chronic diseases and pain conditions.
The mechanisms underlying pain relief of exercise are largely unknown but may be related to the modulation of central descending pain inhibitory pathways after acute exercise bouts. Exercise-induced hypoalgesia (EIH) is typically assessed as the temporary change in PPTs after a short acute exercise bout and EIH is seen as a proxy of descending pain inhibitory control. In general, EIH seems hypoalgesic (functional) in asymptomatic subjects. A hyperalgesic (impaired) EIH response has been reported in different chronic pain populations, although a functional EIH response also has been reported in subgroups of knee osteoarthritis patients. This implies differences in the acute response to exercise between healthy (pain-free) subjects and chronic pain patients, but it is still unknown whether the presence of pain itself affects the pain alleviating response (i.e. the EIH response) to acute exercise.
It is hypothesized that acute pain will decrease the EIH response magnitude following hypertonic saline injection compared with the control injection. This study will increase the insight into the EIH mechanisms in healthy subjects in general, and how the presence of pain affects the body's own ability to modulate pain during exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
盲法说明
The researcher responsible for the statistical analyses are blinded to arm allocation.
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Pain-free
- •Understands and writes Danish
排除标准
- •Pregnancy
- •Previous addictive behavior defined as abuse of hash, opioids or other euphoric substances.
- •Previous painful or mental illnesses, neurological or circulatory diseases in the form of heart or lung disease.
- •Surgery within last 3 months
- •Pain on the days of testing
- •Pain for more than 2 weeks within the last 3 months
结局指标
主要结局
Pressure pain threshold at the right quadriceps muscle where injection is performed.
时间窗: Before and after the 3 minutes wall squat
Between group comparison of the primary outcome, which is change in pressure pain threshold at the right quadriceps muscle from before wall squat to after wall squat. Pressure pain threshold is measured with a hand held pressure algometer.
次要结局
- Pressure pain threshold at the non-dominant trapezius muscle(Before and after the 3 minutes wall squat)
- Pressure pain threshold at the left quadriceps muscle where injection is not performed.(Before and after the 3 minutes wall squat)
- Pain Intensity in thighs(Assessed before and immediately after hypertonic and isotonic saline injection as well as after 1, 2 and 3 min of wall squat, and immediately after the end of wall squat)
研究者
Henrik Bjarke Vægter
Associate Professor in Physiotherapy
Odense University Hospital