The Neural Underpinnings of Disinhibited Eating Behavior in Adolescents With and Without Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Disinhibited eating behavior
研究概览
简要总结
The brain plays an integral role in how and what people eat. However, the brain's contribution to overeating is not well understood during sensitive developmental periods such as adolescence, when excessive weight gain and obesity prevalence are a significant concern.The proposed study will use functional magnetic resonance imaging to examine how the brain's response to excess energy is related to overeating in adolescents with and without obesity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 13 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •male or female
- •13-18 years-old
- •resident of Colorado
排除标准
- •weigh less than 88 pounds or have a BMI% rank of <10% for age and sex;
- •have a physician's diagnosis of metabolic syndrome or diabetes (Type 1 or 2);
- •have a physician's diagnosis of anorexia nervosa or bulimia nervosa;
- •currently taking anti-psychotic medications (not including anti-depressant or anti- anxiety medications);
- •have a non-MRI safe device (e.g. pacemaker or defibrillator) or metal in the body (e.g. metal pins, shrapnel);
- •experience symptoms of claustrophobia when in small or closed-off places;
- •are pregnant or plan to become pregnant
结局指标
主要结局
Disinhibited eating behavior
时间窗: study visit 2; 1.5 hours
Disinhibited eating behavior will be quantified via the kilocalories consumed during the test meal phase of the Eating in the Absence of Hunger laboratory protocol.
Brain function
时间窗: brain imaging visit 1 (study visit 1); 30 minutes
Brain function will be quantified via the blood oxygen level-dependent (BOLD) signal in the hypothalamus, insula, anterior cingulate cortex, nucleus accumbens, amygdala, and superior and inferior frontal gyri, and connectivity between these brain regions.
次要结局
未报告次要终点