NCT00627068已完成不适用
The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
研究概览
简要总结
Our main hypothesis is that EPC function is impaired in some populations with high cardiovascular risk as a result of reduced eNOS-dependent NO production.
详细描述
To determine if a correlation exists between EPC function and eNOS-dependent NO production in EPCs from populations with high versus low cardiovascular risk:
- High and low cardiovascular risk subjects will be identified based on age or history of cardiovascular disease. Endothelial function will be measured by ultrasound.
- EPCs will be isolated from peripheral blood of these subjects. EPC function will be assessed by measuring adhesion to endothelium, migration, proliferation, and differentiation, and compared to their expression and activity of eNOS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Willing and able to give written informed consent and comply with study requirements
- •Adult of 18 years or older
- •Subjects willing to provide blood and tissue samples
排除标准
- •Failure to give informed consent.
- •Those unable to consent for themselves.
- •Those who cannot read English.
- •Patients on Viagra, Levitra, or Cialis
- •Patients with malignant disease
- •Patients with hematological abnormalities
- •Patients with fevers of unknown origin
- •Severe comorbidity or alcohol/drug dependence
- •Women who are post-menopausal and on hormone replacement therapy, or premenopausal and on birth control pills (premenopausal women will be screened verbally and then by assay of LH and FSH levels in blood samples to identify women in the follicular phase of their menstrual cycle, to reduce variability)
研究者
Yerem Yeghiazarians
Assistant Clinical Professor
University of California, San Francisco
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE)PreeclampsiaNCT00653809University of Mississippi Medical Center52
已完成
不适用
Upregulating the Nitric Oxide Pathway To Restore Autonomic Phenotype (UNTRAP).Heart FailureArrhythmiaNCT03658174University of Leicester20
已完成
不适用
Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)Pulmonary Disease, Chronic ObstructiveNCT01398943Augusta University60
已完成
不适用
Analysis of Proteome and Pathophysiological Characteristics of Human Blood CellsRed Blood CellPeripheral Blood Mononuclear CellEndothelial NO-synthaseNCT02272530Heinrich-Heine University, Duesseldorf200
终止
早期 1 期
Does eNOS Gene Polymorphism Play a Role in the Maintenance of Basal Vascular Tone in the Choroid or Optic Nerve Head?Ocular PhysiologyRegional Blood FlowNCT00708357Medical University of Vienna12