Covert Saccade Triggers in Bilateral Vestibular Hypofunction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Latency of covert-saccades
研究概览
简要总结
Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The triggering of these covert-saccade is still not known. They could be of visual origin but the short latency is unusual. The objective of this study is to evaluate the potential role of visual trigger in 12 patients with chronic bilateral areflexia, using different visuo-vestibular conditions. The latency of simple visually guided saccades will also be tested in the group of patients and a group of 12 healthy controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For all :
- •Age from 18 to 90
- •Understanding of the experimental instructions
- •Informed Consent
- •For Patients :
- •Bilateral vestibular hypofunction with regards to the criteria of the of the Barany Society A. Chronic vestibular syndrome with at least three of the following symptoms
- •Postural imbalance
- •Unsteadiness of gait
- •Movement-induced blurred vision or oscillopsia during walking or quick head/body movements
- •Worsening of postural imbalance or unsteadiness of gait in darkness and/or on uneven ground B. No symptoms while sitting or lying down under static conditions C. Bilaterally reduced or absent angular VOR function documented by
- •bilaterally pathological horizontal angular VOR gain < 0.6, measured by the video-HIT5or scleral-coil technique and/or
- •reduced caloric response (sum of bithermal max. peak SPV on each side < 6°/sec7)and/or
- •reduced horizontal angular VOR gain < 0.1 upon sinusoidal stimulation on a rotatorychair (0.1 Hz, Vmax = 50°/sec).
- •D. Not better accounted for by another disease
- •* For Healthy control No ENT or neurological disorders
排除标准
- •Corrected Visual Acuity lower than 5/10
- •Other conditions leading to oscillopsia or ataxia
- •Oculomotor palsy, ocular instability in primary position
- •Treatment that may affect ocular motility (psychotropes)
- •Cervical rachis pathology with instability
- •Cochlear Implants
- •Non-stabilized medical disease
- •Pregnant women
- •Patients under tutelage
- •Patient without social security
结局指标
主要结局
Latency of covert-saccades
时间窗: Day 1
Latency of covert saccades correspond to the time between the beginning of head impulse and the initiation of the first covert-saccade
次要结局
- Frequency of covert-saccades(Day 1)
- Velocity of covert-saccades(day 1)
- Amplitude of covert-saccades(Day 1)
- Latency of visually-guided saccades(Day 1)