Influence of Obesity on Microvascular Reactivity During General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- Recovery slope after general aneshtesia (Tpost)
研究概览
简要总结
The purpose of this study was to investigate the effect of obesity on changes in microvascular reactivity and tissue oxygen saturation (StO2) during general anesthesia using near-infrared spectroscopy in conjunction with vascular occlusion tests (VOT).
For this prospective observation investigation, a total of 128 patients who underwent elective surgery under general anesthesia at Pusan National University Hospital between June 2018 and February 2021 were participated in this study. Baseline StO2 on thenar eminence, hemodynamics, and laboratory profile were monitored before (Tpre) and 30 min after general anesthesia (Tpost). During vascular occlusion tests (VOT), the occlusion slope representing oxygen consumption of muscle and recovery slope representing microvascular reactivity were also collected at Tpre and Tpost. For analysis, the patients were divided into two groups: overweight (body mass index [BMI] ≥ 25 kg/m2) and normal weight (BMI < 25).
详细描述
Preoperative laboratory findings were obtained. Mean blood pressure (MBP), pulse oxygen saturation (SpO2), heart rate (HR), skin temperature, and VOT-derived measurements, including baseline tissue oxygen saturation (StO2), occlusion slope, minimum StO2, time to minimum StO2, recovery slope, maximum StO2, and time to baseline StO2 were recorded before (Tpre) and 30 min after general anesthesia (Tpost).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects who underwent elective surgery under general anesthesia.
排除标准
- •Society of Anesthesiologists (ASA) physical status > II
- •patients with a neuraxial block
- •uncontrolled hypertension
- •patients with major cardiovascular disease
- •pregnant individuals
- •peripheral vascular disease
- •chronic venous insufficiency
- •smoking: Pack-years > 10
- •chronic obstructive and restrictive pulmonary disease
结局指标
主要结局
Recovery slope after general aneshtesia (Tpost)
时间窗: 10 minutes
Representing microvascular reactivity (Tpost: 30 minutes after general anesthesia); recovery slope was calculated from deflation of the tourniquet until the recovery of StO2 to the baseline value.
次要结局
- Recovery slope before general aneshtesia (Tpre)(10 minutes)
- Occlusion slope before general anesthesia (Tpre)(10 minutes)
- Occlusion slope before general anesthesia (Tpost)(10 minutes)
研究者
Hyeon-Jeong Lee
Dr.
Pusan National University Hospital