â??Clinical, epidemiological, serological and molecular characterization of Leptospirosis in patients attending a tertiary care hospital in Karnatakaâ??

Indian Council of Medical Research0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•Objective 1: To compare the various diagnostic tools for accurate diagnosis of human leptospirosis in patients presenting with acute febrile illness.Objective 2: To study serovar-specific clinical characteristics, complications and prognosis of infections by the predominant serovars.
•Objective 3: Molecular characterization of Leptospira by Multilocus sequence typing (MLST).
•Patients of both gender and >18 years of age presenting to the Kasturba Hospital, Manipal and diagnosed with Acute febrile illness (AFI) will be included in this study.
•Fever of <14 days duration with any two of the following signs and symptoms. Myalgia, headache, jaundice, conjunctival suffusion, rash (maculopapular), hepatic dysfunction, GI symptoms (e.g., abdominal pain, nausea, vomiting, diarrhoea), pulmonary complications (ARDS), acute kidney injury (AKI), haemorrhage (e.g., intestinal, pulmonary, haematuria, hematemesis), aseptic meningitis.
•Objective 4:
•Sero-epidemiological study of human leptospirosis amongst high-risk population (farmers) of Udupi District.
•Healthy farmers with no history of fever and antibiotic therapy in the previous two weeks and >18 years of age of both the gender will be included in the study.

•Objective 1: To compare the various diagnostic tools for accurate diagnosis of human leptospirosis in patients presenting with acute febrile illness.
•Objective 2: To study serovar-specific clinical characteristics, complications and prognosis of infections by the predominant serovars.
•Objective 3: Molecular characterization of Leptospira by Multilocus sequence typing (MLST).
•Cases known to have confirmed alternate diagnosis (typhoid, malaria, brucellosis, scrub typhus and dengue) and of <18 years of age will be excluded.
•Objective 4:
•Sero-epidemiological study of human leptospirosis amongst high-risk population (farmers) of Udupi District.
•Farmers having chronic illness of chronic kidney disease, chronic liver disease and diabetes mellitus; history of fever in the previous two weeks; those who have received any antibiotic therapy in the previous two weeks and those of <18 years of age will be excluded from the study.

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