Myocardial Ischemia in Non-obstructive Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 132
- 试验地点
- 1
- 主要终点
- Presence of myocardial ischemia by contrast stress echocardiography
研究概览
简要总结
The aim of the study is to assess presence of myocardial ischemia by contrast stress echocardiography in patients with symptomatic non-obstructive coronary artery disease (CAD) by CT-coronary angiography, and the clinical, vascular, biochemical and genetic markers of myocardial ischemia in such patients.
详细描述
Non-obstructive coronary artery disease (CAD) is particularly common in women and associated with reduced quality of life and increased cardiovascular morbidity and mortality. The project will recruit patients with angina pectoris and non-obstructive CAD by CT- coronary angiography for further imaging with contrast stress echocardiography for diagnosis of myocardial ischemia. Better characterization of patients with symptomatic non-obstructive CAD due to myocardial ischemia will be done by vascular assessment by tonometry, biochemical and genetic markers as well as quality of life questionnaire. This interdisciplinary project is expected to add new knowledge to the impact of multimodality cardiac imaging in improving diagnosis in patients with symptomatic non-obstructive CAD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >30 years
- •Chest pain and or functional dyspnoea with a duration > 6 months
- •Non-obstructive coronary artery disease detected by CT coronary angiography
排除标准
- •Significant coronary artery stenosis or normal coronary arteries by CT coronary angiography
- •Unstable coronary artery disease
- •Significant valvular heart disease
- •Mechanical valve prosthesis
- •Significant arrhythmia
- •Severly reduced pulmonary function (GOLD 3-4)
- •Known allergy to ultrasound contrast agents
- •Pregnancy
- •Inability to sign informed consent to participate
- •Other severe disease
结局指标
主要结局
Presence of myocardial ischemia by contrast stress echocardiography
时间窗: 15 minutes, during contrast stress echocardopgraphy
Presence of delayed myocardial contrast enhancement during stress echocardiography
次要结局
- Extent of myocardial ischemia by contrast stress echocardiography(15 minutes, during contrast stress echocardiography)
研究者
Mai Tone Lønnebakken
MD, phd
University of Bergen