To Determine the Effects of Mycoprotein Consumption on Glucose Absorption in Healthy Participants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Glucose absorption
研究概览
简要总结
Previous research has demonstrated that the food found in Quorn 'Mycoprotein' can lower the blood glucose response to a meal, which may be an important finding for the management of type 2 diabetes. However, it has never been investigated how this lower response occurs, and whether there is dose-dependent response with mycoprotein. The present study will include 12 healthy young adults, who will visit the laboratory for 3 test days, with each day lasting 9 hours. On each visit, separated by a washout period of at least 2 weeks, participants will ingest either a control drink with no mycoprotein, a drink containing 20g mycoprotein or a drink containing 40g mycoprotein. By intravenously infusing labelled glucose during each visit in combination with repeated blood sampling, investigators will determine if the lower blood glucose after mycoprotein ingestion is due to reduced glucose absorption from the gut or increased uptake into body tissues.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Double blind crossover design
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female
- •18-35 years of age
- •Consumption of sufficient amounts of carbohydrate in the diet
- •Body mass index between 18.5 and 30
排除标准
- •Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes), or other form of abnormal glucose metabolism (as this will affect outcome of the study).
- •Any diagnosed cardiovascular disease
- •Insufficient consumption of carbohydrate in the diet
- •A personal or family history of epilepsy, seizures or schizophrenia
- •Known pre-existing liver disease/condition
- •Allergy or intolerance to milk
研究组 & 干预措施
Ingestion of 20g Mycoprotein Drink
Milkshake containing 20g of mycoprotein, 250ml full-fat milk, 50g glucose and 11g lactose is given to participants in one dose
干预措施: Mycoprotein Ingestion (Dietary Supplement)
Ingestion of 40g Mycoprotein Drink
Milkshake containing 40g of mycoprotein, 250ml full-fat milk, 50g glucose and 11g lactose is given to participants in one dose
干预措施: Mycoprotein Ingestion (Dietary Supplement)
Ingestion of Isocaloric Control Drink
Milkshake containing 250ml full-fat milk, 50g glucose, 19g dried skim milk and 9g full-fat dried milk
干预措施: Mycoprotein Ingestion (Dietary Supplement)
结局指标
主要结局
Glucose absorption
时间窗: 6 hours following ingestion of drink
How glucose is absorbed following the ingestion of a mycoprotein drink compared to a placebo control measured using the infusion of stable isotopes
次要结局
- Insulinaemic Response(6 hours following ingestion of drink)
- Incretin Hormones(6 hours following ingestion of drink)
- Production of Short-Chain Fatty Acids(6 hours following ingestion of drink)
- Glucose Kinetics(6 hours following ingestion of drink)