NCT02705911已完成不适用
Isometric Handgrip Exercise: a New Non-pharmacological Tool in the Management of High Blood Pressure?
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- change in office blood pressure at 8 weeks of follow-up
研究概览
简要总结
The purpose of this RCT which will be performed in 60 healthy adults is I. To assess the training effects of 8 weeks of isometric handgrip exercise on BP; and to test whether it yields at least similar effects on BP compared to current exercise recommendations.
II. To assess whether isometric handgrip training yields larger BP reductions beyond the supervised training period at 6 months of follow-up.
III. To determine whether changes in BP following acute exercise and chronic training can be explained by changes in important physiological mechanisms known to mediate or to be associated with BP?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •not physically active (< 3 hours of moderate to high levels of PA/week) low cardiovascular risk according to current guidelines (Mancia et al J Hypertens 2013) will be recruited through advertisements. The latter is defined as:
- •>115 mmHg < systolic BP < 139 mmHg and/or 75 mmHg< diastolic BP<90mmHg in the presence of 0 to a maximum of three other cardiovascular risk factors, excluding diabetes Or
- •139 mmHg < systolic BP < 160 mmHg and/or 90 mmHg<DBP< 100 mmHg in the absence of other cardiovascular risk factors
排除标准
- •current smoker
- •pregnancy
- •presence of other cardiovascular disease, pulmonary disease or metabolic disease
- •inability to perform a standard exercise program due to mental/physical disability.
- •use of antihypertensive drugs
结局指标
主要结局
change in office blood pressure at 8 weeks of follow-up
时间窗: 8 weeks - 6 months
次要结局
- change in exercise tolerance (peakVO2 in ml/min/kg) at 8 weeks of follow-up(8 weeks - 6 months)
研究者
研究点 (2)
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