ISRCTN05135218已完成未知
on-invasive mechanical ventilation with average volume assured pressure support (AVAPS) in patients with chronic obstructive pulmonary disease and hypercapnic encephalopathy: prospective interventional match-controlled study
San Francisco de Quito University (Universidad San Francisco de Quito) (Ecuador)0 个研究点目标入组 22 人开始时间: 2012年9月18日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 22
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Age > 40 years
- •2. COPD was diagnosed on the basis of the recommendations of the American Thoracic Society
- •3. Hypercapnic encephalopathy with GCS < 10 were designated to receive BiPAP S/T with AVAPS
- •4. The control group was then selected from patients in the emergency unit with infectious exacerbations of COPD and encephalopathy (GCS < 10). Patients were treated immediately and referred to us by doctors who were unaware of the study. Each patient was treated with NIV and was selected according to: Acute Physiology and Chronic Health Evaluation II (APACHE II) score within 4 points, age within 10 points, pH within 0.04, GCS within 2 points, and BMI within 2 points
- •5. Informed consent
排除标准
- •1. A face deformity
- •2. Obstruction of the upper respiratory tract owing to recent surgery or trauma
- •3. Alterations in the central nervous system not related to a hypercapnic encephalopathy
- •4. Cardiogenic pulmonary edema, pneumothorax, pulmonary thromboembolism, hemoptysis, or septic shock
- •5. Urgent intubation owing to cardiac and/or respiratory arrest, and hemodynamic instability with a systolic arterial blood pressure (BP) of less than 80mmH
- •6. Other neurological illness
研究者
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