An investigation of the effect of Pulsed Radiofrequency treatment of the Dorsal Root Ganglion on cerebrospinal fluid and peripheral venous blood cellular, proteomic and neuropeptide concentrations with clinical outcome correlation in patients with chronic lumbosacral radicular pain

Trinity Translational Medicine Institute0 个研究点目标入组 10 人开始时间: 2020年1月1日最近更新: 2021年1月5日

适应症

试验速览

暂无简介。

•1. Age range 18-60 years
•2. Unilateral monosegmental radicular pain in the lumbosacral nerve roots
•3. Symptoms consistent with MRI findings of a contained herniated disc
•4. Chronic pain lasting more than 3 months
•5. Failed conservative medical management for over one month (medication and physical therapy)
•6. Radicular pain is the primary complaint with minimal axial pain
•7. NRS of > 3 (on 11-point NRS)

•1. Patient refusal
•2. Atypical or bilateral radicular pain patterns
•3. Axial pain
•4. Cognitive impairment or language barriers that could impair the patients understanding and reporting of outcomes
•5. Malignancy
•6. Vertebral fractures
•7. Multiple sclerosis
•8. Connective tissue diseases
•9. Infection
•10. Pregnancy or breast-feeding
•11. Prior Spinal surgery
•12. Lumbar spine interventions in the last 6 months (epidural injections or PRF)
•13. Coagulation disorder or anti-coagulant treatment
•14. Psychiatric disorder
•15. Allergy to local anesthetics or contrast medium
•16. Dependent Personnel such as staff members, students or NCHDs
•17. Pre-operative NSAID, corticosteroid, methotrexate, monoclonal antibody therapy or opioid therapy
•18. Patients will be excluded from the study if appropriate nerve stimulation during the PRF procedure or pain relief (more than 50%) post DRG block are not achieved

发起方

Trinity Translational Medicine Institute