The Contribution of Incretin Hormones to Post-prandial Glucose Metabolism After Roux-en-Y Gastric Bypass
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- Adrian Vella
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change in Total Disposition Index from Study 1 (Exendin 9,39) to Study 2 (saline)
研究概览
简要总结
The study is being undertaken to understand how the Roux-en-Y Gastric Bypass procedure can affect insulin secretion after meals. The hypothesis of this study is the Disposition Index is decreased in subjects who had previously undergone Roux-en-Y Gastric Bypass by glucagon-like peptide-1 (GLP-1) receptor blockade.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Exendin 9, 39
Exendin 9, 39 will be infused at 300pmol/kg/min in either first intervention period or second intervention period.
干预措施: Exendin 9, 39 (Drug)
Placebo
A saline infusion will be administered in either first intervention period or second intervention period.
干预措施: Placebo (Drug)
结局指标
主要结局
Change in Total Disposition Index from Study 1 (Exendin 9,39) to Study 2 (saline)
时间窗: Day 1, Day 2 (approximately 2 weeks after day 1)
The total disposition index equals the product of insulin secretion and insulin sensitivity.
次要结局
未报告次要终点
研究者
Adrian Vella
Consultant, Endocrinology
Mayo Clinic