Fuel Selection During Eccentric Cycling: Comparison With Concentric Cycling and the Effect of Glucose Ingestion During Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Exogenous glucose oxidation
研究概览
简要总结
This study compares fuel selection during eccentric and concentric cycling, with (placebo) or without glucose ingestion during exercise. After a 2-week familiarization and habituation with the ergometers, subjects will complete four experimental conditions in a randomized order: concentric with placebo, eccentric with placebo, concentric with glucose, eccentric with glucose.
详细描述
Cycling on a cycle ergometer typically requires repeated concentric muscle contractions to push on the pedals and produce mechanical work. An eccentric cycling ergometer has a motor that rotates the cranks with a predetermined torque, the cyclist needs to resist to the movement of the cranks. This leads to eccentric muscle contractions, the work is thus produced while the muscle is lengthening (negative work). This mode of exercise is known to produce a lower oxygen consumption (energy cost) for the same mechanical power output and also leads to muscle damage which can interfere with fuel selection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
Opaque bottles to administer beverages with similar sweet taste.
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Low alcohol consumption (<3 drinks/week)
- •Non-smokers
- •Not regularly taking medication for a known pathology
- •Regularly practices endurance sports (cycling, running, etc.)
排除标准
- •Intolerant to glucose (according to WHO standards)
- •Musculoskeletal injury or illness affecting exercise performance
- •Failure to respect protocol guidelines (diet, exercise prior to experimentation, etc.)
结局指标
主要结局
Exogenous glucose oxidation
时间窗: Average over the 35 minutes of eccentric or concentric exercise
Measured by indirect respiratory calorimetry combined with tracer techniques.
Central and skin temperature
时间窗: Average over the 35 minutes of eccentric or concentric exercise
Measured using a thermometric pill and skin-surface electrodes
Maximal voluntary force production
时间窗: Change between baseline and end of exercise
Measured using isometric bilateral knee extensions
Perceived exertion
时间窗: Average over the 35 minutes of eccentric or concentric exercise
Measured using a Category Ratio scale on 100 points (CR100), 0 signifies no exertion and 100 being maximal effort.
次要结局
- Blood insulin concentration(For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes)
- Blood lactate concentration(For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes)
- Blood glucose concentration(For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes)
- Affective response(Average over the 35 minutes of eccentric or concentric exercise)
- Total carbohydrate, fat and protein oxidation(Average over the 35 minutes of eccentric or concentric exercise)
- Pain perception: VAS(Average over the 35 minutes of eccentric or concentric exercise)
- Blood free-fatty acid concentration(For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes)
研究者
Jonathan Tremblay
Associate Professor
Université de Montréal