The Implications of Tobacco Smoking on Acute Postoperative Pain: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Fagerstrom test for nicotine dependence
研究概览
简要总结
Numbers of postoperative PCA(Patient-Controlled Analgesia) related side effects among current, past and non smokers are determined by comparing and analyzing frequency distributions. To determine whether smokers require more post operative opiate analgesics than others. Multivariate analysis will be performed to identify the major and the minor factors predicting the use of postoperative pain therapy. Our previous related study showed that the smoker male patients consumed more analgesics than those without smoking, but the female group showed the similar findings. However, the case number, especially the female cases, is underpowered. Investigators hope to increase the case number to have a better statistical and clinical significance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients undergoing elective general surgery are assigned to current smokers（n=100） or past smokers（n=100） or never smokers（n=100） according to the questionnaires "Fagerstrom test for nicotine dependence" 1 day prior to the surgery.
排除标准
- •the patients undergoing major thoracic cardiovascular surgery
- •the patients with significant lung lesion
- •the patients with conscious disturbance
- •the patients with allergic history to morphine
结局指标
主要结局
Fagerstrom test for nicotine dependence
时间窗: Post-operation Day1 to Day4
次要结局
- Differences in pain intensity between the three groups after postoperative analgesia.(Post-operation Day1 to Day4)
研究者
Yuan-Yi Chia
anesthesia doctor
Kaohsiung Veterans General Hospital.