Exploring the Effects of Aerobic Exercise Combined with Blood Flow Restriction Training on Exercise Capacity, Cardiopulmonary Functions, and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Oxygen consumption (VO2)
研究概览
简要总结
Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in COPD patients.
详细描述
The systemic effects of Chronic Obstructive Pulmonary Disease (COPD) can precipitate a series of complications, including cardiovascular disorders, muscle atrophy, and osteoporosis. These comorbid conditions often result in decreased physical activity and suboptimal physical fitness, compelling patients to lead a sedentary lifestyle to mitigate exercise-induced dyspnea. Addressing the limitations in exercise tolerance remains a critical therapeutic goal in the treatment of COPD. According to research, exercise intolerance is caused by both poor pulmonary function and associated skeletal muscle dysfunction. Blood flow restriction training, a new rehabilitation technique, has shown promise in improving muscular strength at lower exercise intensities and in shorter timeframes, presenting a fresh approach to COPD rehabilitation.
The research aims to investigate the impact of incorporating blood flow restriction training into a holistic aerobic exercise program on exercise capacity and quality of life among patients with COPD. The findings are intended to clarify the potential of this innovative training technique as a supplementary therapeutic strategy in the management of COPD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •COPD classified as levels 2-
- •Stable condition without worsening in the past three months.
- •No participation in any rehabilitation program within the past six months.
- •Ability to understand and follow verbal commands and cooperate with an exercise training program.
排除标准
- •Unconscious or unable to cooperate with the evaluator.
- •Hospitalization due to acute illness within the past three months.
- •Severe joint diseases or history of lower limb surgery.
- •Severe cardiovascular disease (e.g., presence of a cardiac pacemaker or acute myocardial infarction within the past six months).
- •Dependence on oxygen supply.
结局指标
主要结局
Oxygen consumption (VO2)
时间窗: Change from baseline (0 week) to follow up (20 weeks)
Oxygen consumption examined by cardiopulmonary exercise test
Diaphragm capacity
时间窗: Change from baseline (0 week) to follow up (20 weeks)
Diaphragm capacity examined by diaphragmatic ultrasound
次要结局
- Functional capacity(Change from baseline (0 week) to follow up (20 weeks))
- Heart Rate Variability(Change from baseline (0 week) to follow up (20 weeks))
- Pulmonary function test(Change from baseline (0 week) to follow up (20 weeks))
- Maximum respiratory pressure(Change from baseline (0 week) to follow up (20 weeks))
- Quality of life score (COPD-related questionnaire-I)(Change from baseline (0 week) to follow up (20 weeks))
- Quality of life score (COPD-related questionnaire-II)(Change from baseline (0 week) to follow up (20 weeks))
- Quality of life score (COPD-related questionnaire-III)(Change from baseline (0 week) to follow up (20 weeks))
研究者
Kun-Ling Tsai
Professor and Chair, Department of Physical Therapy
National Cheng Kung University