Description of Physical Activity Effect on Neuromuscular Fatigue of Older People
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 180
- 试验地点
- 2
- 主要终点
- Maximal voluntary contraction (MVC) of the knee extensor muscle measurement
研究概览
简要总结
There is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance with advancing age. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. The aim of this project is to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.
详细描述
With advancing age, there is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance and increases the likelihood that older people will lose their independence. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. Indeed, recent data support the idea that it is fitness level, not age that explains physiological responses to exercise. However, although there are data about how quickly cardiovascular and neuromuscular functions decline throughout life, less is known on the extent physical activity can help mitigate the loss of these functions. The aim of this project is therefore to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 18 to 35 for the young group, between 65 and 80 for the old group and over 80 for the very old group.
- •Signed consent for the study obtained
- •Subject affiliated or entitled to a social security scheme
排除标准
- •Pathology or surgical intervention causing a locomotor disorder
- •Neurological, cardiovascular or psychological pathology
- •Participants will be excluded if resting or exercise ECG responses show any abnormality, or if resting Heart Rate (HR) > 100 bmp, resting blood pressure > 144 (systolic) / 95 (diastolic) mmHg, pulmonary and or cardiac disease that could affect the health of the participant (arrhythmias and stroke)
- •Mini-Mental State Examination score < 20 (>80 years old)
- •Significant change in the amount of physical practice over the last 5 years.
结局指标
主要结局
Maximal voluntary contraction (MVC) of the knee extensor muscle measurement
时间窗: At 48 hours
Maximal isometric force (maximal voluntary contraction, MVC) of the knee extensor muscle measured before and after an incremental test on a bicycle ergometer
次要结局
- Cardiac variability(ms)(At 48 hours)
- Muscle oxygenation (%)(At 48 hours)
- Test of Get-up-and-Go (s)(At 48 hours)
- Maximal voluntary contraction (MVC) of the hand grip measurement(At 48 hours)
- Voluntary activation measurement (%)(At 48 hours)
- Maximal voluntary contraction (MVC) of the plantar flexor muscle measurement(At 48 hours)
- Balance test (s)(At 48 hours)
- Reaction force on the ground for each step (N)(At 72 hours)
- Maximal oxygen consumption (VO2max) during an effort test on a cycloergometer(At 72 hours)
- Functional Assessment of Chronic Illness Therapy (FACIT) questionnaire(At inclusion)
- Quality of life via the SF-36 questionnaire(At inclusion)