NL-OMON34645已完成3 期
Dopamine-serotonin dysbalance and the relation to myoclonus and psychiatric co-morbidity in patients with dystonia - Dopamine-serotonin dysbalance in dystonia
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 83
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age between 35 and 80 years old
- •Primary generalized, segmental or focal dystonia with or without jerks
- •Informed consent
- •Botulinum toxin injections in the Academic Medical Center
- •Stable Tsui scale for severity of dystonia for at least one year
排除标准
- •Other neurological conditions at inclusion or in the past
- •Treatment with deep brain stimulation for dystonia
- •SSRI use in the past 6 months prior to or during the study
- •Use of other anti-depressants during the study, especially MAO-B inhibitors
- •Symptomatic therapy for dystonia other than botulinum toxin, e.g. baclofen or other muscle relaxants.
- •Use of medication with a known effect on dopamine or serotonin receptors or transporters or with a known interaction with escitalopram (e.g. L-DOPA, dopamine-agonists, ritalin, NSAID*s, aspirin, tryptophan, carbamazepine, etcetera)
- •Pregnancy or nursing
研究者
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