The Effect of Aerobic Exercise on Genetic Molecules Related With Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 3
- 主要终点
- genetic molecules
研究概览
简要总结
The aim of this study is to compare the effects of high intensity interval exercise and moderate intensity continuous exercise on some genetic molecules in patients with type 2 diabetes mellitus.
详细描述
Volunteers with type 2 diabetes mellitus will be evaluated in terms of any contra-indication that will restrain them from making exercise. 90 male or female volunteers who are suitable in terms of inclusion/exclusion criteria will be invited for the study. Volunteers will be randomly distributed to one of the 3 groups. Each group will contain 30 participants. 1. group will make aerobic exercise which is in the form of high intensity interval exercise 2.group will make aerobic exercise which is in the form of moderate intensity continuous exercise 3. Control group. Exercise groups will be cycling under observation in the hospital setting. Control group will make simple stretching exercises at home. Participants will be requested to complete a 3 months of exercise. They will be evaluated before and at the end of the 3 months of exercise with blood tests to measure genetic molecules related with metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
Participants wil be making exercise. It is not possible to make participants blinded to the study.
入排标准
- 年龄范围
- 30 Years 至 74 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinica diagnosis of type 2 Diabetes mellitus less than 10 years and more than 1 year.
- •must have appropriate medical therapy and diet.
- •must not be treated with insulin.
- •must be exercising less than 210 minutes/ week
排除标准
- •prominent cardiovascular disease
- •coronary artery disease
- •moderate to severe valvular disease
- •atrial fibrillation
- •untreated hypertension
- •congenital heart disease
- •retinopathy
- •neuropathy
- •macro albuminuria
- •cerebrovascular disease
- •ejection fraction less than 40
- •body mass index greater than
- •prominent ischemic changes in EKG at rest or during exercise.
- •cigarette or alcohol addiction
- •on drugs that interferes with body fat distribution (such as insulin, thiazolidinediones
结局指标
主要结局
genetic molecules
时间窗: 12 weeks
HbA1c level in the serum
次要结局
未报告次要终点
研究者
GULIN FINDIKOGLU
Associate Professor
Pamukkale University