The Effects of Short-term Cognitive Training on Cognition and Mood Symptoms in Late-life Depression: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Changes in cognitive functions including fluid intelligence, executive function, language, memory and motor speed
研究概览
简要总结
The purpose of this study is to examine the effects of the alternative uses training (AUT) and word association training (WAT) on cognitive functions and mood symptoms in late-life depression (LLD).
The hypotheses are:
- post-training cognitive performance will be superior to pre-training cognitive performance
- post-training depressive symptomatology will be less severe as compared with pre-training clinical severity and
- AUT group will show better post-training cognitive performance and improved mood symptoms when compared with the WAT group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female
- •Age >=55
- •Proficiency in English
- •Current depressive episode and meet criteria for DSM-IV major depressive disorder
- •Hamilton Depression Rating Scale score >=15
- •Able to give informed consent
- •Stable medication dosages during the training period
排除标准
- •Other DSM-IV Axis I psychiatric disorders, except for anxiety disorders due to high comorbidity with mood disorders
- •Mini-Mental State Examination score of <26
- •Diagnosis of dementia
- •Neurological and medical conditions known to affect cognition (e.g., stroke, head injury, previous chemotherapy for cancer)
- •Unstable medical illnesses requiring active treatment
- •Vision or hearing impairment affecting ability to participate in training
研究组 & 干预措施
Alternative Uses Training
In this task, subjects are asked to produce atypical and alternative uses for common daily objects.
干预措施: Cognitive training (Behavioral)
Word Association Training
In this task, subjects are asked to generate the first word that comes to their mind, and thus, encourages more general and spontaneous divergent thinking.
干预措施: Cognitive training (Behavioral)
结局指标
主要结局
Changes in cognitive functions including fluid intelligence, executive function, language, memory and motor speed
时间窗: Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day
Computerized Executive Tasks: * Number-Letter Task * Letter-Memory Task * Stroop Task Non-Computerized Measures: * Cattell Culture Fair Intelligence Test * Mattis Dementia Rating Scale-2 (DRS-2)
次要结局
- Changes in mood including depression, anxiety and apathy(Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day)
研究者
Linda Mah, MD
Clinician Scientist
Rotman Research Institute at Baycrest