NCT00523497终止不适用
Noninvasive Mechanical Ventilation in Severe Community-Acquired Pneumonia and Acute Hypoxemic Respiratory Failure. A Prospective, Randomized and Controlled Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 试验地点
- 2
- 主要终点
- The primary aim of this study was to compare the effects of NIMV on mortality rate and length of stay at the ICU with the effects of CMV
研究概览
简要总结
The purpose of this study is to determine whether the noninvasive ventilation is more effective in the treatment of severe comunity acquired pneumonia in comparison with the conventional mechanical ventilation with orotracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The criteria for the diagnosis of SCAP included:
- •Blood systolic pressure lower than 90 mmHg or blood diastolic pressure lower than 60 mmHg
- •RR higher than 30 breaths per minute
- •PaO2/FiO2 lower than 250 while breathing through a Venturi mask with a 50% inspired oxygen fraction (FiO2)
- •Bilateral or multiple lobar infiltrations evidenced by thorax X-ray, and
- •Use of vasopressor drugs
排除标准
- •Exclusion criteria included:
- •Acute cardiogenic pulmonary edema
- •Severe haemodynamic instability (arterial systolic pressure lower than 70 mmHg) or requirements of vasoactive drugs
- •Glasgow score equal to or lower than 9 or requiring OTI for airway protection or for recent pulmonary resucitation
- •Antecedents of respiratory failure resulting from neuromuscular pathology
- •Failure of two or more organs
- •Facial deformities; and
- •Recent facial, aesophagic and gastric surgeries
结局指标
主要结局
The primary aim of this study was to compare the effects of NIMV on mortality rate and length of stay at the ICU with the effects of CMV
时间窗: 3 years
次要结局
- The secondary aims were to evaluate the incidence and the complications of OTI as well as to compare the improvements in the gas exchange.(3 years)
研究者
研究点 (2)
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