NCT05930600已完成不适用
Internal Jugular Venous Distensibility Index and Innominate Venous Flow Patterns As Predictors of Response to Fluid Administration in Elective Surgery Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 79
- 试验地点
- 1
- 主要终点
- IJV distensibility index correlation to fluid responsiveness
研究概览
简要总结
The measurement of internal jugular vein distensibility index corresponds to the measurement of stroke volume using trans-thoracic Doppler echocardiography in assessing the response to fluid administration in elective surgical patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Utilizing intraoperative mechanical ventilation with a tidal volume of 8 ml/kg (PBW).
- •ASA physical status 1-
- •Mongoloid ethnicity.
- •Willing to participate in the research and sign the informed consent.
排除标准
- •Patients with symptoms and signs of fluid overload, such as pulmonary edema, pleural effusion, ascites, and peripheral edema.
- •Patients with chronic or acute kidney dysfunction, renal replacement therapy history, and/or oliguria (urine output <0.5 ml/kg/hour).
- •Patients with cardiovascular diseases, including heart failure, cardiac arrhythmias, moderate-to-severe valvular abnormalities, a history of angina/myocardial infarction, pulmonary hypertension, and peripheral artery disease.
- •Patients with anatomical abnormalities in the neck and chest region that make it impractical to perform jugular vein ultrasound and transthoracic echocardiography.
- •Jugular vein thrombosis.
- •Superior vena cava syndrome.
- •Placement of jugular vein catheter.
- •Body mass index (BMI) greater than 30.0 kg/m
- •Patients with contraindications to the use of muscle relaxants.
- •Patients with lung hyperinflation and pleural effusion.
- •Drop out criteria:
- •Patients who wish to withdraw from the study.
- •Post-anesthesia induction complications and emergencies.
- •Transthoracic echocardiography provides a less representative image due to difficult acoustic window.
结局指标
主要结局
IJV distensibility index correlation to fluid responsiveness
时间窗: 1 day
Correlation between IJV distensibility index and fluid responsiveness defined as increase of stroke volume more than 10% after fluid challenge
次要结局
- Innominate vein flow velocity correlation to fluid responsiveness(1 day)
- Comparison of IJV distensibility index in fluid responders and non-fluid responders.(1 day)
- Detection of sensitivity, specificity, positive predictive value, negative predictive value, and best cut off value of IJV distensibility index to predict fluid responsiveness(1 day)
- Correlation of IJV distensibility index and stroke volume(1 day)
研究者
Dita Aditianingsih
Principal investigator, MD, PhD, Anesthesiologist Consultant
Indonesia University
研究点 (1)
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