Correlation Between Muscle Thickness and Inflammation With Ventilator Length of Use in Critically Ill Patients: Study on Diaphragm Thickness, Rectus Femoris and Biceps Brachii Cross-sectional Area, and C-reactive Protein Level
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Correlation between changes in diaphragm thickness with ventilator length of use
研究概览
简要总结
Decrease thickness of diaphragm muscle, cross-sectional area of rectus femoris and biceps brachii muscle, and increase in CRP would affect ventilator length of use in critically ill patients in ICU
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who had Modified Rankin Score < 4 in 1 month before admitted into ICU
排除标准
- •Pregnant women
- •Patients who had intubation more than 24 hours before admitted at ICU Cipto Mangunkusumo Hospital
- •Patients who had a history or prior to thoracic or heart surgery 14 days before admission
- •Patients who had severe peripheral muscle dysfunction
- •Patients who had a history of admission in hospital for more than 2 weeks on the last 3 months
- •Patients who predicted will be using ventilator for less than 4 days
- •Patients who suffered acute respiratory distress syndrome (ARDS) with a ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) less than 200
- •Patients who declined to participate in this study
结局指标
主要结局
Correlation between changes in diaphragm thickness with ventilator length of use
时间窗: 30 days from admission
Correlation between changes in diaphragm thickness with ventilator length of use: \< 7 days or \>7 days
Correlation between changes in cross-sectional area of rectus femoris muscle with ventilator length of use
时间窗: 30 days from admission
Correlation between changes in cross-sectional area of rectus femoris muscle with ventilator length of use: \< 7 days or \>7 days
Correlation between changes in cross-sectional area of biceps brachii muscle with ventilator length of use
时间窗: 30 days from admission
Correlation between changes in cross-sectional area of biceps brachii muscle with ventilator length of use: \< 7 days or \>7 days
Correlation between changes in quantitative C-reactive protein (CRP) level with ventilator length of use
时间窗: 30 days from admission
Correlation between changes in quantitative C-reactive protein (CRP) level with ventilator length of use: \< 7 days or \>7 days
次要结局
- Changes in diaphragm thickness(5 days from admission)
- Changes in cross-sectional area of biceps brachii muscle(5 days from admission)
- Changes in quantitative C-reactive protein (CRP) levels(5 days from admission)
- Changes in cross-sectional area of rectus femoris muscle(5 days from admission)
- Ventilator length of use(30 days from admission)
研究者
Dita Aditianingsih
MD, PhD, Anesthesiologist Consultant
Indonesia University