Characterization of Circulating Tumor Cells Captured by c-MET (CTC-MET)

Duke University2 个研究点分布在 1 个国家目标入组 62 人开始时间: 2014年3月1日最近更新: 2017年8月1日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 62
试验地点: 2
主要终点: Feasibility

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This pilot study will aim to determine whether circulating tumor cells (CTCs) can be captured using the novel cMET based ferrofluid. The primary objective of this pilot study will be to describe the numbers of c-MET expressing cells that can be detected by the c-MET CTC capture technique. These data will be separated by disease site. The investigator will also describe the detection rates of both the c-MET CTC capture and the EpCAM CTC capture techniques in each patient, also separated by disease site.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Single Group
主要目的: Device Feasibility
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Prostate cancer patients will be eligible for inclusion in this study only if all of the following criteria apply:
•Histologically confirmed diagnosis of adenocarcinoma of the prostate. Small cell or neuroendocrine tumors of the prostate are also permitted.
•Clinical or radiographic evidence of metastatic disease.
•Castrate levels of testosterone (<50 ng/dl)
•Enrollment prior to the initiation of a new systemic therapy.
•Evidence of disease progression on or following most recent therapy as evidenced by either of the following:
•Two consecutive PSA levels greater than the PSA nadir achieved on ADT and most recent therapy, separated by greater than one week
•Radiographic evidence of disease progression as defined by new bone scan lesions or growth of soft tissue/visceral metastases >1 cm in diameter (2 cm for lymph nodes).
•Clinical progression of disease with cutaneous lesions or palpable lesions in absence of radiographic progression
•Age > 18 years.
•Ability to understand and the willingness to sign a written informed consent document.
•Renal cell carcinoma patients will be eligible for inclusion in this study only if all of the following inclusion criteria apply:
•Histologically confirmed diagnosis of invasive renal cell carcinoma (all histologies)
•Clinical or radiographic evidence of metastatic disease.
•Evidence of disease progression on the current or following the most recent therapy, as defined by one of the following:
•A new soft tissue/visceral/lymph node/bone metastatic lesion
•Growth of existing soft tissue/visceral/lymph node/bone metastases as determined by the investigator
•Clinical progression of disease with cutaneous lesions or palpable lesions in absence of radiographic progression
•For clear cell carcinoma, refractory to treatment with VEGF inhibitors as defined by progression on VEGF therapy within 1 year of starting VEGF therapy. For non-clear cell histologies, any line of systemic therapy.
•Enrollment prior to the initiation of a new systemic therapy.
•Age > 18 years.
•Ability to understand and the willingness to sign a written informed consent document.
•Bladder cancer patients will be eligible for inclusion in this study only if all of the following inclusion criteria apply:
•Histologically confirmed diagnosis of invasive bladder transitional cell carcinoma, adenocarcinoma, squamous cell carcinoma, or small cell carcinoma.
•Metastatic disease with either bone or visceral metastatic lesions, or clinically symptomatic with metastatic disease.
•Progression of disease on or following the most recent treatment as evidenced by one of the following:
•A new soft tissue/visceral/lymph node/bone metastatic lesion
•Growth of existing soft tissue/visceral/lymph node/bone metastases as determined by the investigator.
•Clinical progression of disease with cutaneous lesions, palpable lesions, pleural effusions, or ascites in absence of radiographic progression
•Enrollment prior to the initiation of a new systemic therapy.
•Age > 18 years.
•Ability to understand and the willingness to sign a written informed consent document.
•Gastric cancer (including gastroesophageal junction) patients will be eligible for inclusion in this study only if all of the following inclusion criteria apply:
•Histologically confirmed diagnosis of invasive gastric or distal esophageal adenocarcinoma.
•Clinical or radiographic evidence of metastatic disease.
•Evidence of disease progression on or following the most recent therapy, as defined by one of the following:
•New soft tissue/visceral/lymph node/bone metastatic lesion
•Growth of existing soft tissue/visceral/lymph node/bone metastases as determined by the investigator
•Clinical progression of disease with cutaneous lesions, palpable lesions, pleural effusions, or ascites in absence of radiographic progression
•Enrollment prior to the initiation of a new systemic therapy.
•Age > 18 years.
•Ability to understand and the willingness to sign a written informed consent document.
•Colorectal cancer patients will be eligible for inclusion in this study only if all of the following inclusion criteria apply:
•Histologically confirmed diagnosis of invasive colorectal adenocarcinoma.
•Clinical or radiographic evidence of metastatic disease.
•Evidence of disease progression on the current or following the most recent therapy, as defined by one of the following:
•New soft tissue/visceral/lymph node/bone metastatic lesion
•Growth of existing soft tissue/visceral/lymph node/bone metastases as determined by the investigator
•Clinical progression of disease with cutaneous lesions, palpable lesions, pleural effusions, or ascites in absence of radiographic progression
•Enrollment prior to the initiation of a new systemic therapy.
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排除标准

•A patient will not be eligible for inclusion in this study if any of the following criteria apply:
•History of intercurrent or past medical or psychiatric illness that would make participation in a blood drawing protocol difficult or not feasible at the discretion of the principal investigator or co-investigator(s).
•Treatment with an anthracycline (including mitoxantrone, doxorubicin, epirubicin, and daunorubicin) within 1 week of CTC collection (applicable in prostate and gastric cancer patients), as anthracyclines cause auto-fluorescence of cells.