Hyperalgesia After Deep Electrical Stimulation in Pain Free Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Change in skin pain detection threshold before and during deep electrical pain stimulation.
研究概览
简要总结
Sensory disturbances in persistent postherniotomy pain, include hyperalgesia from deeper structures as well as the skin. Whether this is one combined pain syndrome, where for instance deep pain leads to cutaneous hyperalgesia, or two isolated synchronous pain conditions, is unknown. By Giving pain free subjects an intense non-harmful electrical stimulation in deeper tissues in the groin and recording the skin sensory function, this hypothesis will be tested
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •male, age >18 yr, pain-free, caucasian
排除标准
- •previous groin surgery, groin hernia, sensory disturbaces, use of painmedication, drug or alcohol abuse.
结局指标
主要结局
Change in skin pain detection threshold before and during deep electrical pain stimulation.
时间窗: 14 days
Heat pain detection threshold by use of a Thermotester (Somedic AS Sweden) is assessed before and during deep electrical pain stimulation (6 of 10 point on a NRS scale. Deep pain stimulation is performed by two needle electrodes, placed under ultrasound guidance, 5 mm apart in various tissue and locations in the groin: 1. Musculus rectus abdominis dxt. ( 10 cm craniel to the external inguinal ring) - Subcutaneous, and muscular stimulation. 2. Spina iliaca anterior superior dxt. ( 2 cm lateral to the ilica spine) - subcutaneous, m obliquus externus and nervns ilioinguinalis stimulation. 3. External inguinal ring - subcutaneous and funicle stimulation.
次要结局
- Test-retest of primary outcome(14 days)
研究者
Eske Kvanner Aasvang
M.D.
Rigshospitalet, Denmark