Collection of Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- levels of miRNAs in the blood and CSF
研究概览
简要总结
In normal patients, blood and cerebrospinal fluid (CSF) contain circulating cells and other molecules such as proteins and nucleic acids. In patients with central nervous system (CNS) and other conditions, the levels of these molecules may be altered. In several other studies at our institution, the investigators are investigating such molecules in tumor specimens as well as the blood and cerebrospinal fluid of pediatric patients with CNS tumors. However, these levels are difficult to interpret without comparing them to levels in patients without CNS tumors. The investigators propose a study to collect small amounts of blood and cerebrospinal fluid from pediatric patients without CNS tumors who are undergoing a diagnostic or therapeutic neurosurgical procedure aimed at addressing altered CSF dynamics.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Year 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children without central nervous system tumors who are undergoing a neurosurgical procedure to address hydrocephalus during which CSF will be obtained
- •Between the ages of 1 year and 21 years
- •Patients must be having blood draws, lumbar punctures or CSF sampling from Ommaya reservoirs or VPS as part of routine clinical care.
排除标准
- •Patients who do not require routine blood draws and/or CSF collection as part of their routine clinical care
- •Patients who are considered too ill to participate as determined by their treating physician
- •Patients with documented bacterial of viral infections of the CSF, brain parenchyma and/or neurosurgical devices and/or
- •Patients with suspected de-myelinating conditions
- •Patients who are pregnant or lactating.
结局指标
主要结局
levels of miRNAs in the blood and CSF
时间窗: 2 yrs
次要结局
- Survivin and biologic markers levels in the CSF and blood(2 yrs)
研究者
Rishi Lulla
Principal Investigator
Ann & Robert H Lurie Children's Hospital of Chicago