A Randomized Controlled Trial to compare the effectiveness of cyproterone acetate /ethinyl estradiol, desogestrel / ethinyl estradiol and metformin on improving hirsutism, hormonal and metabolic features of polycystic ovary syndrome.

niversity Grants Commission, Sri Lanka0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年8月20日

适应症

试验速览

暂无简介。

•1.Age more than 18 years and less than 40 years
•2.Diagnosis of PCOS according to the 2003 Rotterdam Consensus conference criteria
•3.One or more of the following dermatological manifestations of hyperandrogenism: hirsutism, androgenetic alopecia, acne

•1. Smoking, alcoholism, drug addiction
•2. Current pregnancy.
•3. Current or previous use (up to three months before the study) of oral, vaginal, monthly injectable, or transdermal combined hormonal contraceptives
•4. Current or previous use (up to six months before the study) of a long-lasting hormonal contraceptive method (injectable, implant, or intrauterine device)
•5. Current use of antiandrogens, hypoglycemic drugs, statins
•6. Presence of systemic diseases (diabetes mellitus, cardiovascular disease, autoimmune diseases, liver disease, thyroid disease, or congenital adrenal hyperplasia)
•7. Personal history of arterial or venous thrombosis
•8. Puerperium of 24 weeks or less
•9. Psychiatric illness or on anti-psychotic drugs
•10. Renal disease
•11. Migraine
•12. Other causes of hyperandrogenism
•13. Women wishing to conceive during the next 12 months
•14. Personal or family history of breast carcinoma
•15. Women with contraindications to use oral contraceptives (WHO criteria) and metformin
•16. Inability to give the informed consent
•17. History of metformin use within the previous 8 weeks

发起方

niversity Grants Commission, Sri Lanka