The Effect of Aerobic Exercise on the Irisin/Klotho/Sirtuin-1/BDNF Axis: A Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Salivary Irisin Level
研究概览
简要总结
The purpose of this study is to investigate the effects of an acute aerobic exercise on irisin, klotho, sirtuin-1, and BDNF levels in the healthy adults. The findings will help understand the physiological impacts of exercise on these biomarkers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Being between the ages of 18 and 45
- •Being in good health and having no diagnosis of any chronic disease
- •Not having taken regular medication within the last 4 weeks
- •Voluntary participation and providing written informed consent
排除标准
- •Individuals with a history of cardiovascular, endocrine, metabolic, or renal disease
- •Individuals with a history of active infection, musculoskeletal injury, or severe disability
- •Individuals with any medical condition that might prevent participation in exercise
- •Individuals unable to regularly participate in the exercise protocol throughout the study
研究组 & 干预措施
Experimental Group
Aerobic exercise
干预措施: Aerobic exercise (Behavioral)
Control Group
No exercise
结局指标
主要结局
Salivary Irisin Level
时间窗: Baseline- immediately after exercise and 1 hours after exercise
Irisin concentration will be determined from a saliva sample using the ELISA technique.
Salivary Klotho Level
时间窗: Baseline- immediately after exercise and 1 hours after exercise
Klotho concentration will be determined from a saliva sample using the ELISA technique.
Salivary Sirtuin Level
时间窗: Baseline- immediately after exercise and 1 hours after exercise
Sirtuin concentration will be determined from a saliva sample using the ELISA technique.
Salivary BDNF Level
时间窗: Baseline- immediately after exercise and 1 hours after exercise
BDNF concentration will be determined from a saliva sample using the ELISA technique.
次要结局
- Saliva Flow Rate(Baseline- İmmediately after exercise and 1 hour after exercise)
研究者
Cemre Didem Eyipinar
Research Assistant
University of Gaziantep