Investigating the neural correlates of repeated tDCS in MCI and healthy ageing with fMRI - Neural correlates of repeated tDCS

niversiteit Maastricht0 个研究点目标入组 80 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•- Diagnosis of MCI based on the latest research criteria (clinical assessment at the memory clinic (prof. Frans RJ Verhey): presence of at least a memory impairment, memory complaints expressed by the patient or informant, no problems in daily life functioning, no dementia and presence of biomarkers (Albert et al., 2011)
•- Clinical Dementia Rating score of 0.5 (CDR distinguishes a stage of questionable dementia (CDR 0.5) from people termed healthy (CDR 0) and those with mild dementia (CDR 1)
•- Mini-Mental State Examination (MMSE) 23 and being mentally competent (in general, individuals with a MMSE 18 are considered mentally competent)
•- Age: between 60 and 85 years old
•- 50% female
•- Right-handedness
•- Average level of education (CBS level 3-4-5-6);Healthy controls
•- Average neuropsychological test results, in accordance with normative data, corrected for age, education and gender
•- No substantial memory complaints (according to the participant)
•- Age: between 60 and 85 years old
•- 50% female
•- Right-handedness
•- Average level of education (CBS level 3-4-5-6)
•- Normal or corrected to normal vision

•- Psychoactive medication use
•- Abuse of alcohol and drugs
•- Cognitive impairment due to alcohol/drug abuse or abuse of other substances
•- Past or present psychiatric or neurological disorders (major depression, schizophrenia, bipolar disorder, psychotic disorder (or treatment for it), epilepsy, stroke, Parkinson*s disease, multiple sclerosis, brain surgery, brain trauma, electroshock therapy, kidney dialysis, Menière*s disease, brain infections)
•- Major vascular disorders (e.g. stroke)
•- Heart diseases or pacemakers
•- Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, body tattoos)
•- Large scars or fresh wounds on the scalp

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