A New Zealand Neuroimaging Study of Repetitive TranscranialMagnetic Stimulation (rTMS) in Treatment-Resistant Depression as assessed by the Montgomery–Åsberg Depression Rating Scale.

The university of Auckland0 个研究点目标入组 32 人开始时间: 2018年12月3日最近更新: 2021年12月27日

适应症

试验速览

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•Patient is willing and able to give informed consent for participation in the trial
•Male or female, aged 18 years or above
•In the Investigators’ opinion, is able and willing to comply with all trial requirements
•Major depressive disorder for at least three months, as assessed by a Clinical Interview using DSM-IV criteria
•MADRS >20
•An inadequate response to at least two antidepressants courses one of which can include the current episode.

•Contraindications to repetitive transcranial magnetic stimulation, assessed using the University of Auckland safety checklist
•Contraindications for MRI as per the CAMRI screening form
•History of psychosis
•Any unstable medical or neurologic condition
•Planned major changes to psychotropic medication
•Imminent risk of suicide as determined by the CSSRS and clinical interview with a consultant psychiatrist
•Planned or probable use of ECT
•>2 years of depressive episode
•Substance abuse or dependence in previous 6 months
•Any other condition judged by the treating clinician as likely to impact on the ability of the participant to complete the trial
•Regular use of any medication deemed to be contraindicating as judged by the screening physicians
•Inability to speak or read English

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